Rubella virus genotype 2B endemicity and related utility of serum-based molecular characterization in Uganda

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dc.contributor.authorPhionah Tushabe
dc.contributor.authorBarnabas Bakamutumaho
dc.contributor.authorEliku, James Peter
dc.contributor.authorBirungi, Molly
dc.contributor.authorAine, Francis
dc.contributor.authorNamuwulya, Prossy
dc.contributor.authorBukenya, Henry
dc.contributor.authorAmpeire, Immaculate
dc.contributor.authorKisakye, Annet
dc.contributor.authorByabamazima, Charles R.
dc.contributor.authorBwogi, Josephine
dc.date.accessioned2025-03-09T17:28:07Z
dc.date.available2025-03-09T17:28:07Z
dc.date.issued2023
dc.description.abstractThere are 13 globally recognized rubella virus genotypes of which only 2 (1E and 2B) have been detected recently. The largest percentage of all reported rubella virus sequences come from China and Japan with Africa reporting limited data. In a bid to address the lack of rubella genotype data in Uganda and the World Health Organization Africa region, we sought to characterize rubella viruses retrospectively using sera collected from suspected measles patients that turned out rubella IgM positive. Seven sequences belonging to genotype 2B sub-lineage 2B-L2c were obtained. These sequences clustered with other genotype 2B sequences previously reported from Uganda. None of the other genotypes (1E and 1G) reported from Uganda in the earlier years were detected. In addition, none of the sequences were obtained after the introduction of the measles-rubella containing vaccine. The above highlight the need for continuous rubella virological surveillance to confirm interruption of endemic rubella genotype circulation.
dc.identifier.citationTushabe, P., Bakamutumaho, B., Eliku, J. P., Birungi, M., Aine, F., Namuwulya, P., ... & Bwogi, J. (2023). Rubella virus genotype 2B endemicity and related utility of serum-based molecular characterization in Uganda. BMC Research Notes, 16(1), 218. https://doi.org/10.1186/s13104-023-06499-5
dc.identifier.urihttps://doi.org/10.1186/s13104-023-06499-5
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/10092
dc.language.isoen
dc.publisherBMC Research Notes
dc.titleRubella virus genotype 2B endemicity and related utility of serum-based molecular characterization in Uganda
dc.typeArticle
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