Antioxidant and anti-plasmodial activity of extracts from three Ugandan medicinal plants

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dc.contributor.authorStangeland, Torunn
dc.contributor.authorWangensteen, Helle
dc.contributor.authorKatuura, Esther
dc.contributor.authorLye, Kare A.
dc.contributor.authorPaulsen, Berit S.
dc.date.accessioned2021-12-14T11:47:57Z
dc.date.available2021-12-14T11:47:57Z
dc.date.issued2010
dc.description.abstractExtracts from three plants; Hallea rubrostipulata, Vernonia adoensis and Zanthoxylum chalybeum, were tested for antioxidant activity using three assays 2,2-Diphenyl-1-picrylhydrazyl (DPPH), Ferric Reducing Ability of Plasma (FRAP) and total phenol content) and anti-plasmodial activity using an Enzyme-Linked Immunosorbent Assay (ELISA) on Plasmodium falciparum chloroquine sensitive strain MRA-285 line. The objective of the study was to find candidates for making anti-malarial phytomedicines. The water extract of H. rubrostipulata showed very high anti-plasmodial activity (IC50= 1.95 μg/ml) and high antioxidant activity as well. Thirteen other extracts had high anti-plasmodial activity ranging from 2.14 to 3.63 μg/ml (chloroquine IC50= 8 μg/ml). We found high correlation between the different antioxidant essaysen_US
dc.identifier.citationStangel, T., Wangensteen, H., Katuura, E., Lye, K. A., & Paulsen, B. S. (2010). Antioxidant and anti-plasmodial activity of extracts from three Ugandan medicinal plants. Journal of Medicinal Plants Research, 4(18), 1916-1923.DOI: 10.5897/JMPR10.446en_US
dc.identifier.issnISSN 1996-0875
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/491
dc.language.isoenen_US
dc.publisherJournal of Medicinal Plants Researchen_US
dc.subjectHallea rubrostipulataen_US
dc.subjectVernonia adoensisen_US
dc.subjectZanthoxylum chalybeumen_US
dc.subject2,2-Diphenyl-1-picrylhydrazylen_US
dc.subjectFluorescence recovery after photobleachingen_US
dc.subjectTotal phenolic compoundsen_US
dc.titleAntioxidant and anti-plasmodial activity of extracts from three Ugandan medicinal plantsen_US
dc.typeArticleen_US
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