Suboptimal Nevirapine Steady-State Pharmacokinetics During Intrapartum Compared With Postpartum in HIV-1–Seropositive Ugandan Women

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dc.contributor.authorLamorde, Mohammed
dc.contributor.authorByakika-Kibwika, Pauline
dc.contributor.authorOkaba-Kayom, Violet
dc.contributor.authorFlaherty, John P.
dc.contributor.authorBoffito, Marta
dc.contributor.authorNamakula, Rhoda
dc.contributor.authorRyan, Mairin
dc.contributor.authorNakabiito, Clemensia
dc.contributor.authorBack, David J.
dc.contributor.authorKhoo, Saye
dc.contributor.authorMerry, Concepta
dc.contributor.authorScarsi, Kimberly K.
dc.date.accessioned2022-01-13T17:12:25Z
dc.date.available2022-01-13T17:12:25Z
dc.date.issued2010
dc.description.abstractConflicting data exist regarding the effect of pregnancy on steady-state nevirapine pharmacokinetics (PK), although steady-state nevirapine concentrations during pregnancy have never been characterized in sub-Saharan Africa. Methods: This was a longitudinal intensive PK study in Ugandan pregnant women receiving nevirapine-based antiretroviral therapy. Participants underwent intensive 12-hour PK sampling during the second trimester (T2; n = 4), third trimester (T3; n = 15) and 6 weeks postpartum (PP; n = 15). HIV-1 RNAwas performed within 2weeks of each visit. Nevirapine C12 above 3000 ng/mLwas classified as optimal based on the suggested value for therapeutic drug monitoring.en_US
dc.identifier.citationLamorde, M., Byakika-Kibwika, P., Okaba-Kayom, V., Flaherty, J. P., Boffito, M., Namakula, R., ... & Scarsi, K. K. (2010). Suboptimal Nevirapine Steady-State Pharmacokinetics During Intrapartum Compared With Postpartum in HIV-1–Seropositive Ugandan Women. Journal of acquired immune deficiency syndromes (1999), 55(3), 345.en_US
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594885/
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1269
dc.language.isoenen_US
dc.publisherJournal of acquired immune deficiency syndromesen_US
dc.subjectAntiretroviral agentsen_US
dc.subjectHIVen_US
dc.subjectPregnancyen_US
dc.subjectPharmacokineticsen_US
dc.subjectSub-Saharan Africaen_US
dc.titleSuboptimal Nevirapine Steady-State Pharmacokinetics During Intrapartum Compared With Postpartum in HIV-1–Seropositive Ugandan Womenen_US
dc.typeArticleen_US
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