Metabolite changes in blood predict the onset of tuberculosis

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dc.contributor.authorWeiner, January
dc.contributor.authorMaertzdorf, Jeroen
dc.contributor.authorSuliman, Sara
dc.contributor.authorHanekom, Willem A.
dc.contributor.authorMayanja-Kizza, Harriet
dc.contributor.authorKaufmann, Stefan H.E.
dc.contributor.authorGC6-74 consortium
dc.date.accessioned2022-05-25T11:49:34Z
dc.date.available2022-05-25T11:49:34Z
dc.date.issued2018
dc.description.abstractNew biomarkers of tuberculosis (TB) risk and disease are critical for the urgently needed control of the ongoing TB pandemic. In a prospective multisite study across Subsaharan Africa, we analyzed metabolic profiles in serum and plasma from HIV-negative, TB-exposed individuals who either progressed to TB 3–24 months post-exposure (progressors) or remained healthy (controls). We generated a trans-African metabolic biosignature for TB, which identifies future progressors both on blinded test samples and in external data sets and shows a performance of 69% sensitivity at 75% specificity in samples within 5 months of diagnosis. These prognostic metabolic signatures are consistent with development of subclinical disease prior to manifestation of active TB. Metabolic changes associated with pre-symptomatic disease are observed as early as 12 months prior to TB diagnosis, thus enabling timely interventions to prevent disease progression and transmission.en_US
dc.identifier.citationWeiner, J., Maertzdorf, J., Sutherland, J. S., Duffy, F. J., Thompson, E., Suliman, S., ... & Kaufmann, S. H. (2018). Metabolite changes in blood predict the onset of tuberculosis. Nature communications, 9(1), 1-12.https://doi.org/10.1038/s41467-018-07635-7en_US
dc.identifier.issn2041-1723
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/3330
dc.language.isoenen_US
dc.publisherNature communicationsen_US
dc.subjectDiagnostic markers, Metabolomics, Predictive medicine, Tuberculosisen_US
dc.titleMetabolite changes in blood predict the onset of tuberculosisen_US
dc.typeArticleen_US
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