Prevalence and correlates of chronic obstructive pulmonary disease and chronic respiratory symptoms in rural southwestern Uganda: a cross-sectional, population-based study

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dc.contributor.authorNorth, Crystal M.
dc.contributor.authorKakuhikire, Bernard
dc.contributor.authorVořechovská, Dagmar
dc.contributor.authorKigozi, Simone Hausammann
dc.contributor.authorMcDonough, Amy Q.
dc.contributor.authorDowney, Jordan
dc.contributor.authorChristiani, David C.
dc.contributor.authorTsai, Alexander C.
dc.contributor.authorSiedner, Mark J.
dc.date.accessioned2021-12-17T13:28:49Z
dc.date.available2021-12-17T13:28:49Z
dc.date.issued2019
dc.description.abstractThe global burden of chronic obstructive pulmonary disease (COPD) disproportionately affects resource-limited settings such as sub-Saharan Africa (SSA), but population-based prevalence estimates in SSA are rare. We aimed to estimate the population prevalence of COPD and chronic respiratory symptoms in rural southwestern Uganda.Adults at least 18 years of age who participated in a population-wide census in rural southwestern Uganda completed respiratory questionnaires and lung function testing with bronchodilator challenge at health screening events in June 2015. We defined COPD as post-bronchodilator forced expiratory volume in one second to forced vital capacity ratio less than the lower limit of normal. We fit multivariable linear and log binomial regression models to estimate correlates of abnormal lung function and respiratory symptoms, respectively. We included inverse probability of sampling weights in models to facilitate population-level estimates.Forty-six percent of census participants (843/1814) completed respiratory questionnaires and spirometry, of which 565 (67%) met acceptability standards. COPD and respiratory symptom population prevalence were 2% (95% confidence interval (CI)  = 1%-3%) and 30% (95% CI = 25%-36%), respectively. Respiratory symptoms were more prevalent and lung function was lower among women and ever-smokers (P < 0.05). HIV serostatus was associated with neither respiratory symptoms nor lung function.COPD population prevalence was low despite prevalent respiratory symptoms. This work adds to the growing body of literature depicting lower-than-expected COPD prevalence estimates in SSA and raises questions about whether the high respiratory symptom burden in rural southwestern Uganda represents underlying structural lung disease not identified by screening spirometry.en_US
dc.identifier.citationNorth, C. M., Kakuhikire, B., Vořechovská, D., Hausammann-Kigozi, S., McDonough, A. Q., Downey, J., ... & Siedner, M. J. (2019). Prevalence and correlates of chronic obstructive pulmonary disease and chronic respiratory symptoms in rural southwestern Uganda: a cross-sectional, population-based study. Journal of global health, 9(1).North, Crystal M et al. “Prevalence and correlates of chronic obstructive pulmonary disease and chronic respiratory symptoms in rural southwestern Uganda: a cross-sectional, population-based study.” Journal of global health vol. 9,1 (2019): 010434. doi:10.7189/jogh.09.010434en_US
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/747
dc.language.isoenen_US
dc.publisherJournal of global healthen_US
dc.titlePrevalence and correlates of chronic obstructive pulmonary disease and chronic respiratory symptoms in rural southwestern Uganda: a cross-sectional, population-based studyen_US
dc.typeArticleen_US
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