Non-tuberculous mycobacteria isolated from slaughter pigs in Mubende district, Uganda

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dc.contributor.authorMuwonge, Adrian
dc.contributor.authorKankya, Clovice
dc.contributor.authorJohansen, Tone B.
dc.contributor.authorDjønne, Berit
dc.contributor.authorGodfroid, Jacques
dc.contributor.authorBiffa, Demelash
dc.contributor.authorEdvardsen, Vigdis
dc.contributor.authorSkjerve, Eystein
dc.date.accessioned2022-02-04T16:43:00Z
dc.date.available2022-02-04T16:43:00Z
dc.date.issued2012
dc.description.abstractThe importance of infections caused by non-tuberculous mycobacteria (NTM) in animals and humans has gained considerable recognition during the past few years. In the developed world, where pig production is extensively practiced, studies on mycobacterial infections and related control strategies have received increasing attention. The infections are reported to be caused by a wide spectrum of NTM. Unfortunately, these infections have been less recognized in sub-Saharan Africa owing to lack of awareness and systematic studies. In this study we aimed at isolating and identifying species of mycobacteria involved in causing infections in slaughter pigs in Mubende district of Uganda. Furthermore we wanted to identify factors associated with infection prevalence in the study area. Methods: A total of 363 lymph nodes were collected and cultured for the presence of mycobacteria. Isolates were identified by 16S rDNA gene sequencing. A questionnaire survey was administered to identify production related factors associated with infection prevalence. Data were assembled and analysed using descriptive statistics and mixed effects logistic regression analysis. Results: Mycobacteria were detected in 39 % (143/363) of the examined lymph nodes, 63 % (59/93) of lymph nodes with gross lesions typical of mycobacteriosis and 31% (84/270) of lymph nodes with no visible lesions. Nineteen per cent of the isolated mycobacteria were identified as Mycobacterium (M) avium, of these 78% and 22% were M. avium sub sp. Hominissuis and avium respectively. Other mycobacterial species included M. senuense (16%), M. terrae (7%) and M. asiaticum (6%). This study found free range systems (OR = 3.0; P = 0.034) and use of water from valley dams (OR = 2.0; P = 0.049) as factors associated with high prevalence of mycobacteria in slaughter pigs. Conclusions: This study demonstrated a high prevalence of NTM infections among slaughter pigs in Mubende district of Uganda. M. avium was the most prevalent of all NTM isolated and identified. Free range system of pig management and valley dam water were the most significant factors associated with NTM prevalence in Mubende district. These findings could be of a major public health concern given that it is in a predominantly pork consuming population with 18% HIV/AIDS prevalence. Therefore, stringent post-mortem inspection at the slaughter houses is of paramount importance to reduce human exposure.en_US
dc.identifier.citationMuwonge et al.: Non-tuberculous mycobacteria isolated from slaughter pigs in Mubende district, Uganda. BMC Veterinary Research 2012 8:52. doi:10.1186/1746-6148-8-52en_US
dc.identifier.other10.1186/1746-6148-8-52
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1920
dc.language.isoenen_US
dc.publisherBMC Veterinary Researchen_US
dc.subjectNon-tuberculous mycobacteriaen_US
dc.subjectSlaughter pigsen_US
dc.subjectMubende districten_US
dc.subjectUgandaen_US
dc.titleNon-tuberculous mycobacteria isolated from slaughter pigs in Mubende district, Ugandaen_US
dc.typeArticleen_US
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