Elevated blood pressure among children born to women with obstructed labour in Eastern Uganda: a cohort study

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dc.contributor.authorMukunya, David
dc.contributor.authorMusaba, Milton W
dc.contributor.authorNambozo, Brendah
dc.contributor.authorOguttu, Faith
dc.contributor.authorMakoko, Brian Tonny
dc.contributor.authorNapyo, Agnes
dc.contributor.authorNantale, Ritah
dc.contributor.authorWani, Solomon
dc.contributor.authorTumuhamye, Josephine
dc.contributor.authorAuma, Prossy
dc.contributor.authorAtim, Ketty
dc.contributor.authorWamulugwa, Joan
dc.contributor.authorNahurira, Doreck
dc.contributor.authorOkello, Dedan
dc.contributor.authorSsegawa, Lawrence
dc.contributor.authorWandabwa, Julius
dc.contributor.authorKiguli, Sarah
dc.contributor.authorChebet, Martin
dc.date.accessioned2024-02-08T11:38:47Z
dc.date.available2024-02-08T11:38:47Z
dc.date.issued2024-02
dc.description.abstractAbstract BACKGROUNDGlobally, high systolic blood pressure accounts for 10.8 million deaths annually. The deaths are disproportionately higher among black people. The reasons for this disparity are poorly understood, but could include a high burden of perinatal insults such as birth asphyxia. Therefore, we aimed to assess the incidence of elevated blood pressure and to explore associated factors among children born to women with obstructed labour. METHODS We followed up children born to women with obstructed labour aged 25 to 44 months at Mbale regional referral hospital that had participated in the sodium bicarbonate trial ( Trial registration number PACTR201805003364421) between October 2021 and April 2022. Our primary outcome was elevated blood pressure defined as blood pressure (either systolic or diastolic or both) ≥ the 90th percentile for age, height, and sex in the reference population based on the clinical practice guideline for screening and management of high blood pressure in children and adolescents. We used logistic regression to estimate odds ratios between selected exposures and elevated blood pressure. RESULTS The incidence of elevated blood pressure was (39/140, 27.9%: 95% (CI: 20.6-36.1)). Participants aged three years and above had twice the odds of elevated blood pressure as those aged less than three years (Adjusted odds ratio (AOR) 2.46: 95% CI (1.01-5.97). Female participants had 2.81 times the odds of elevated blood pressure as their male counterparts (AOR 2.81 95% CI (1.16-6.82). Participants with reduced estimated glomerular filtration rate had 2.85 times the odds of having elevated blood pressure as those with normal estimated glomerular filtration rate (AOR 2.85 95% CI (1.00-8.13). We found no association between arterial cord lactate, stunting, wealth index, exclusive breastfeeding, food diversity and elevated blood pressure. CONCLUSION Our findings show a high incidence of elevated blood pressure among children. We encourage routine checking for elevated blood pressure in the pediatric population particularly those with known risk factors.en_US
dc.identifier.citationMukunya, David, Milton W. Musaba, Brendah Nambozo, et al. 'Elevated Blood Pressure among Children Born to Women with Obstructed Labour in Eastern Uganda: A Cohort Study', Clinical Hypertension, vol. 30/no. 1, (2024), pp. 4-4.en_US
dc.identifier.issnISSN 2056-5909
dc.identifier.issnEISSN 2056-5909
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/9402
dc.language.isoenen_US
dc.publisherBioMed Central Ltden_US
dc.subjectElevated blood pressure, Obstructed labour, Uganda, Birth asphyxia, Pediatric hypertensionen_US
dc.titleElevated blood pressure among children born to women with obstructed labour in Eastern Uganda: a cohort studyen_US
dc.typeArticleen_US
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