Transmitted antiretroviral drug resistance among newly HIV-1 diagnosed young individuals in Kampala

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dc.contributor.authorNdembi, Nicaise
dc.contributor.authorHamers, Raph
dc.contributor.authorLyagoba, Frederick
dc.contributor.authorMagambo, Brian
dc.contributor.authorNanteza, Bridget
dc.contributor.authorWatera, Christine
dc.contributor.authorKaleebu, Pontiano
dc.contributor.authorRinke, de Wit
dc.date.accessioned2023-03-07T12:12:48Z
dc.date.available2023-03-07T12:12:48Z
dc.date.issued2011
dc.description.abstractTo assess the emergence of transmitted HIV-1 drug resistance (TDR) in Kampala, Uganda, 10 years after the scale-up of antiretroviral treatment (ART) and to compare with a previous survey among antenatal clinic attendees in 2007 (reporting 0% TDR). A cross-sectional survey was conducted among newly HIV-1 diagnosed, antiretroviral-naive young adults attending two large voluntary counseling and testing centers within the geographic area of Kampala. Proxy criteria for recent HIV-1 infection were used as defined by the WHO. Population sequencing of the pol gene was performed on plasma samples with HIV-1 RNA at least 1000 copies/ml. Surveillance drug resistance mutations (SDRMs) were identified according to the 2009 WHO list for surveillance of TDR. HIV-1 subtypes were designated using maximum likelihood phylogenetic reconstruction. Genotypic test results were obtained for 70 of 77 (90.9%) participants. SDRMs were identified in six samples yielding a prevalence of TDR of 8.6% (95% confidence interval 3.2–17.7%). Two had SDRMs to nucleoside reverse-transcriptase inhibitors (D67G and L210W), three had SDRMs to nonnucleoside reverse transcriptase inhibitors (G190A, G190S, and K101E), and one had SDRMs to protease inhibitors (N88D). Frequencies of HIV-1 subtypes were A (36/70, 51.4%), C ( two of 70; 2.9%), D (23/70, 32.9%), and unique recombinant forms (nine of 70, 12.9%). This repeated survey suggests an increase in TDR in Kampala, compared with a previous survey. This finding justifies increased vigilance with respect to surveillance of TDR in areas in Africa where ART programs are rolled-out.en_US
dc.identifier.citationNdembi, N., Hamers, R. L., Sigaloff, K. C., Lyagoba, F., Magambo, B., Nanteza, B., ... & De Wit, T. F. R. (2011). Transmitted antiretroviral drug resistance among newly HIV-1 diagnosed young individuals in Kampala. Aids, 25(7), 905-910.DOI: 10.1097/QAD.0b013e328346260fen_US
dc.identifier.issn0269-9370
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8110
dc.language.isoenen_US
dc.publisherAidsen_US
dc.subjecttransmitted drug resistanceen_US
dc.subjectsurveillanceen_US
dc.subjectsubtypeen_US
dc.subjectantiretroviral therapyen_US
dc.subjectHIV-1en_US
dc.titleTransmitted antiretroviral drug resistance among newly HIV-1 diagnosed young individuals in Kampalaen_US
dc.typeArticleen_US
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