Human Papillomavirus Genotype Attribution in Invasive Cervical Cancer: a Retrospective Cross-sectional Worldwide Study

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dc.contributor.authorSanjose, Silvia de
dc.contributor.authorAlemany, Laia
dc.contributor.authorLloveras, Belen
dc.contributor.authorRuiz, Patricia Alonso de
dc.contributor.authorLima, Marcus Aurelho
dc.contributor.authorGuimera, Nuria
dc.contributor.authorClavero, Omar
dc.contributor.authorAlejo, Maria
dc.contributor.authorLlombart-Bosch, Antonio
dc.contributor.authorTatti, Silvio Alejandro
dc.contributor.authorAlejandro, Silvio
dc.contributor.authorKasamatsu, Elena
dc.contributor.authorOdida, Michael
dc.contributor.authorJain, Asha
dc.contributor.authorLombardi, Luis Estuardo
dc.contributor.authorBanjo, Aekunbiola
dc.contributor.authorLerma, Enrique
dc.contributor.authorSasagawa, Toshiyuki
dc.contributor.authorToshiyuki
dc.date.accessioned2023-02-28T09:56:48Z
dc.date.available2023-02-28T09:56:48Z
dc.date.issued2010
dc.description.abstractKnowledge about the distribution of human papillomavirus (HPV) genotypes in invasive cervical cancer is crucial to guide the introduction of prophylactic vaccines. We aimed to provide novel and comprehensive data about the worldwide genotype distribution in patients with invasive cervical cancer. Paraffin-embedded samples of histologically confirmed cases of invasive cervical cancer were collected from 38 countries in Europe, North America, central South America, Africa, Asia, and Oceania. Inclusion criteria were a pathological confirmation of a primary invasive cervical cancer of epithelial origin in the tissue sample selected for analysis of HPV DNA, and information about the year of diagnosis. HPV detection was done by use of PCR with SPF-10 broad-spectrum primers followed by DNA enzyme immunoassay and genotyping with a reverse hybridisation line probe assay. Sequence analysis was done to characterise HPV-positive samples with unknown HPV types. Data analyses included algorithms of multiple infections to estimate type-specific relative contributions. 22 661 paraffin-embedded samples were obtained from 14 249 women. 10 575 cases of invasive cervical cancer were included in the study, and 8977 (85%) of these were positive for HPV DNA. The most common HPV types were 16, 18, 31, 33, 35, 45, 52, and 58 with a combined worldwide relative contribution of 8196 of 8977 (91%, 95% CI 90–92). HPV types 16 and 18 were detected in 6357 of 8977 of cases (71%, 70–72) of invasive cervical cancer. HPV types 16, 18, and 45 were detected in 443 of 470 cases (94%, 92–96) of cervical adenocarcinomas. Unknown HPV types that were identified with sequence analysis were 26, 30, 61, 67, 69, 82, and 91 in 103 (1%) of 8977 cases of invasive cervical cancer. Women with invasive cervical cancers related to HPV types 16, 18, or 45 presented at a younger mean age than did those with other HPV types (50·0 years [49·6–50·4], 48·2 years [47·3–49·2], 46·8 years [46·6–48·1], and 55·5 years [54·9–56·1], respectively). To our knowledge, this study is the largest assessment of HPV genotypes to date. HPV types 16, 18, 31, 33, 35, 45, 52, and 58 should be given priority when the cross-protective effects of current vaccines are assessed, and for formulation of recommendations for the use of second-generation polyvalent HPV vaccines. Our results also suggest that type-specific high-risk HPV-DNA-based screening tests and protocols should focus on HPV types 16, 18, and 45.en_US
dc.identifier.citationDe Sanjose, S., Quint, W. G., Alemany, L., Geraets, D. T., Klaustermeier, J. E., Lloveras, B., ... & Bosch, F. X. (2010). Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study. The lancet oncology, 11(11), 1048-1056.https://doi.org/10.1016/S1470-2045(10)70230-8en_US
dc.identifier.issn1470-2045
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8015
dc.language.isoenen_US
dc.publisherThe lancet oncologyen_US
dc.subjectHuman papillomavirusen_US
dc.subjectgenotypeen_US
dc.subjectinvasive cervical canceren_US
dc.subjectretrospectiveen_US
dc.titleHuman Papillomavirus Genotype Attribution in Invasive Cervical Cancer: a Retrospective Cross-sectional Worldwide Studyen_US
dc.typeArticleen_US
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