Building clinical pharmacology laboratory capacity in low- and middle-income countries: Experience from Uganda

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dc.contributor.authorOmali, Denis
dc.contributor.authorBuzibye, Allan
dc.contributor.authorKwizera, Richard
dc.contributor.authorByakika-Kibwika, Pauline
dc.contributor.authorNamakula, Rhoda
dc.contributor.authorMatovu, Joshua
dc.contributor.authorMbabazi, Olive
dc.contributor.authorMande, Emmanuel
dc.contributor.authorSekaggya-Wiltshire, Christine
dc.contributor.authorNakanjako, Damalie
dc.contributor.authorGutteck, Ursula
dc.contributor.authorMcAdam, Keith
dc.contributor.authorEasterbrook, Philippa
dc.contributor.authorKambugu, Andrew
dc.contributor.authorFehr, Jan
dc.contributor.authorCastelnuovo, Barbara
dc.contributor.authorManabe, Yukari C.
dc.contributor.authorLamorde, Mohammed
dc.contributor.authorMueller, Daniel
dc.contributor.authorMerry, Concepta
dc.date.accessioned2023-03-03T17:08:37Z
dc.date.available2023-03-03T17:08:37Z
dc.date.issued2023
dc.description.abstractResearch and clinical use of clinical pharmacology laboratories are limited in low- and middle-income countries. We describe our experience in building and sustaining laboratory capacity for clinical pharmacology at the Infectious Diseases Institute, Kampala, Uganda. Intervention: Existing laboratory infrastructure was repurposed, and new equipment was acquired. Laboratory personnel were hired and trained to optimise, validate, and develop in-house methods for testing antiretroviral, anti-tuberculosis and other drugs, including 10 high-performance liquid chromatography methods and four mass spectrometry methods. We reviewed all research collaborations and projects for which samples were assayed in the laboratory from January 2006 to November 2020. We assessed laboratory staff mentorship from collaborative relationships and the contribution of research projects towards human resource development, assay development, and equipment and maintenance costs. We further assessed the quality of testing and use of the laboratory for research and clinical care. Lessons learnt: Fourteen years post inception, the clinical pharmacology laboratory had contributed significantly to the overall research output at the institute by supporting 26 pharmacokinetic studies. The laboratory has actively participated in an international external quality assurance programme for the last four years. For clinical care, a therapeutic drug monitoring service is accessible to patients living with HIV at the Adult Infectious Diseases clinic in Kampala, Uganda. Recommendations: Driven primarily by research projects, clinical pharmacology laboratory capacity was successfully established in Uganda, resulting in sustained research output and clinical support. Strategies implemented in building capacity for this laboratory may guide similar processes in other low- and middle-income countries.en_US
dc.identifier.citationOmali D, Buzibye A, Kwizera R, et al. Building clinical pharmacology laboratory capacity in low- and middle-income countries: Experience from Uganda. Afr J Lab Med. 2023;12(1), a1956. https://doi.org/10.4102/ajlm.v12i1.1956en_US
dc.identifier.urihttps://doi.org/10.4102/ajlm.v12i1.1956
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8063
dc.language.isoenen_US
dc.publisherAfrican Journal of Laboratory Medicineen_US
dc.subjectTherapeutic drug monitoringen_US
dc.subjectBuilding laboratory capacityen_US
dc.subjectResource-limited settingen_US
dc.subjectHIVen_US
dc.titleBuilding clinical pharmacology laboratory capacity in low- and middle-income countries: Experience from Ugandaen_US
dc.typeArticleen_US
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