No evidence for association between APOL1 kidney disease risk alleles and Human African Trypanosomiasis in two Ugandan populations

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dc.contributor.authorMagambo, Phillip K.
dc.contributor.authorNoyes, Harry
dc.contributor.authorMulindwa, Julius
dc.contributor.authorEnyaru, John
dc.contributor.authorAlibu, Vincent P.
dc.contributor.authorSidibe, Issa
dc.contributor.authorMumba Ngoyi, Dieuodonne
dc.contributor.authorHertz-Fowler, Christiane
dc.contributor.authorMacLeod, Annette
dc.contributor.authorTastan Bishop, Ozlem
dc.contributor.authorMatovu, Enock
dc.date.accessioned2022-12-07T12:00:13Z
dc.date.available2022-12-07T12:00:13Z
dc.date.issued2018
dc.description.abstractHuman African trypanosomiasis (HAT) manifests as an acute form caused by Trypanosoma brucei rhodesiense (Tbr) and a chronic form caused by Trypanosoma brucei gambiense (Tbg). Previous studies have suggested a host genetic role in infection outcomes, particularly for APOL1. We have undertaken candidate gene association studies (CGAS) in a Ugandan Tbr and a Tbg HAT endemic area, to determine whether polymorphisms in IL10, IL8, IL4, HLAG, TNFA, TNX4LB, IL6, IFNG, MIF, APOL1, HLAA, IL1B, IL4R, IL12B, IL12R, HP, HPR, and CFH have a role in HAT. Methodology and results We included 238 and 202 participants from the Busoga Tbr and Northwest Uganda Tbg endemic areas respectively. Single Nucleotide Polymorphism (SNP) genotype data were analysed in the CGAS. The study was powered to find odds ratios > 2 but association testing of the SNPs with HAT yielded no positive associations i.e. none significant after correction for multiple testing. However there was strong evidence for no association with Tbr HAT and APOL1 G2 of the size previously reported in the Kabermaido district of Uganda. Conclusions/Significance A recent study in the Soroti and Kaberamaido focus in Central Uganda found that the APOL1 G2 allele was strongly associated with protection against Tbr HAT (odds ratio = 0.2, 95% CI: 0.07 to 0.48, p = 0.0001). However, in our study no effect of G2 on Tbr HAT wasen_US
dc.identifier.citationKimuda MP, Noyes H, Mulindwa J, Enyaru J, Alibu VP, Sidibe I, et al. (2018) No evidence for association between APOL1 kidney disease risk alleles and Human African Trypanosomiasis in two Ugandan populations. PLoS Negl Trop Dis 12(2): e0006300. https://doi. org/10.1371/journal.pntd.0006300en_US
dc.identifier.urihttps://doi.org/10.1371/journal.pntd.0006300
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/6039
dc.language.isoenen_US
dc.publisherPLoS neglected tropical diseasesen_US
dc.subjectkidney diseaseen_US
dc.subjectTrypanosomiasisen_US
dc.subjectUgandan populationsen_US
dc.titleNo evidence for association between APOL1 kidney disease risk alleles and Human African Trypanosomiasis in two Ugandan populationsen_US
dc.typeArticleen_US
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