Evaluation of current rapid HIV test algorithms in Rakai, Uganda

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dc.contributor.authorGaliwango, Ronald M.
dc.contributor.authorMusoke, Richard
dc.contributor.authorLubyayi, Lawrence
dc.contributor.authorSsekubugu, Robert
dc.contributor.authorKalibbala, Sarah
dc.contributor.authorSsekweyama, Viola
dc.contributor.authorMirembe, Viola
dc.contributor.authorNakigozi, Gertrude
dc.contributor.authorReynolds, Steven J.
dc.contributor.authorSerwadda, David
dc.contributor.authorGray, Ronald H.
dc.contributor.authorKigozi, Godfrey
dc.date.accessioned2022-01-20T21:06:28Z
dc.date.available2022-01-20T21:06:28Z
dc.date.issued2013
dc.description.abstractRapid HIV tests are a crucial component of HIV diagnosis in resource limited settings. In Uganda, the Ministry of Health allows for both serial and parallel HIV rapid testing using Determine, Stat- Pak and Uni-Gold. In serial testing, a non-reactive result on Determine ends testing. The performance of serial and parallel algorithms with Determine and Stat-Pak test kits was assessed. A cross-sectional diagnostic test accuracy evaluation using three rapid HIV test kits as per the recommended parallel test algorithm was followed by EIA-WB testing with estimates of the performance of serial testing algorithm. In 2520 participants tested by parallel rapid algorithms, 0.6% had weakly reactive result. Parallel testing had 99.7% sensitivity and 99.8% specificity. If Stat-Pak was used as the first screening test for a serial algorithm, the sensitivity was 99.6% and specificity 99.7%. However, if Determine was used as the screening test, sensitivity was 97.3% and specificity 99.9%. Serial testing with Stat-Pak as the initial screening test performed as well as parallel testing, but Determine was a less sensitive screen. Serial testing could be cost saving.en_US
dc.identifier.citationGaliwango, R. M., Musoke, R., Lubyayi, L., Ssekubugu, R., Kalibbala, S., Ssekweyama, V., ... & Kigozi, G. (2013). Evaluation of current rapid HIV test algorithms in Rakai, Uganda. Journal of virological methods, 192(1-2), 25-27. doi:10.1016/j.jviromet.2013.04.003.en_US
dc.identifier.other10.1016/j.jviromet.2013.04.003.
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1363
dc.language.isoenen_US
dc.publisherJournal of virological methodsen_US
dc.subjectHIV test algorithmsen_US
dc.subjectRakaien_US
dc.subjectUgandaen_US
dc.titleEvaluation of current rapid HIV test algorithms in Rakai, Ugandaen_US
dc.typeArticleen_US
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