Health-related quality of life in epilepsy patients receiving anti-epileptic drugs at National Referral Hospitals in Uganda: a cross-sectional study

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dc.contributor.authorNabukenya, Anne M.
dc.contributor.authorMatovu, Joseph K. B.
dc.contributor.authorWabwire-Mangen, Fred
dc.contributor.authorWanyenze, Rhoda K.
dc.contributor.authorMakumbi, Fredrick
dc.date.accessioned2021-12-11T11:54:47Z
dc.date.available2021-12-11T11:54:47Z
dc.date.issued2014
dc.description.abstractEpilepsy is a devastating disorder that impacts on patients’ quality of life, irrespective of use of anti epileptic drugs (AEDs). This study estimates the health-related quality of life (HRQOL) and its associated predictors among epilepsy patients receiving AEDs. Methods: A total of 175 epilepsy patients already receiving AED for at least 3 months were randomly selected and interviewed from mental clinics at Mulago and Butabika national referral hospitals in Uganda between May - July 2011. A HRQOL index, the primary outcome, was constructed using items from Quality Of Life in Epilepsy Inventory (QOLIE-31) and the Hospital Anxiety and Depression Scale (HADS) questionnaires. The internal consistency and adequacy of these items was also computed using Cronbach's alpha and Kaiser-Meyer-Olkin tests. Partial correlations were used to evaluate the contribution of the health dimensions (mental, psychological, social, physical functioning and emotional well being) and, multiple linear regressions to determine factors independently associated with HRQOL. Results: Just about half of the respondents (54%) were males, and nearly two thirds (62%) had received AEDs for at least 12 months. The average age was 26.6 years (SD = 11.1). The overall HRQOL mean score was 58 (SD = 13) on a scale of 0–100. The average scores of different dimensions or subscales ranged from 41 (physical) to 65 (psychological). At least three quarters (75%) of all subscales had good internal consistency and adequacy. The largest variations in the overall HRQOL were explained by social and mental functioning; each accounting for about 30% of the difference in the HRQOL but seizure control features explained a little (6%) variation. Factors negatively associated with HRQOL were poly-therapy (−1.16, p = 0.01) and frequency of seizures (−2.29, p = 0.00). Other factors associated with overall HRQOL included drug side effects, sex, marital status and education. Duration on AEDs was not a significant predictor of HRQOL. Conclusion: The HRQOL for epilepsy patients on AEDs is very low. The predictors of low HRQOL were socio factors (marital status, education) and drug side effects, frequency of seizure, and type of therapy.en_US
dc.identifier.citationNabukenya et al.: Health-related quality of life in epilepsy patients receiving anti-epileptic drugs at National Referral Hospitals in Uganda: a cross-sectional study. Health and Quality of Life Outcomes 2014 12:49. doi:10.1186/1477-7525-12-49en_US
dc.identifier.other10.1186/1477-7525-12-49
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/315
dc.language.isoenen_US
dc.publisherHealth and Quality of Life Outcomesen_US
dc.subjectEpilepsyen_US
dc.subjectSeizuresen_US
dc.subjectAnti-epileptic drugsen_US
dc.subjectQOLIE and health related quality of lifeen_US
dc.titleHealth-related quality of life in epilepsy patients receiving anti-epileptic drugs at National Referral Hospitals in Uganda: a cross-sectional studyen_US
dc.typeArticleen_US
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