Hepatitis B virus and sexual behavior in Rakai, Uganda

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dc.contributor.authorStabinski, Lara
dc.contributor.authorReynolds, Steven J.
dc.contributor.authorOcama, Ponsiano
dc.contributor.authorLaeyendecker, Oliver
dc.contributor.authorSerwadda, David
dc.contributor.authorGray, Ron H.
dc.contributor.authorWawer, Maria
dc.contributor.authorThomas, David L.
dc.contributor.authorQuinn, Thomas C.
dc.contributor.authorKirk, Gregory D.
dc.date.accessioned2022-04-30T20:04:33Z
dc.date.available2022-04-30T20:04:33Z
dc.date.issued2011
dc.description.abstractHIV and hepatitis B virus (HBV) co-infection poses important public health considerations in resource-limited settings. Demographic data and sera from adult participants of the Rakai Health Sciences Program Cohort in Southwestern Uganda were examined to determine HBV seroprevalence patterns in this area of high HIV endemicity prior to the introduction of antiretroviral therapy. Commercially available EIAs were used to detect prevalent HBV infection (positive for HBV core antibody [anti-HBc] and/or positive HBV surface antigen [HBsAg]), and chronic infection (positive for HBsAg). Of 438 participants, 181 (41%) had prevalent HBV infection while 21 (5%) were infected chronically. Fourteen percent of participants were infected with HIV. Fifty three percent showed evidence of prevalent HBV infection compared to 40% among participants infected with HIV (p=0.067). Seven percent of participants infected with HIV were HBsAg positive compared to 4% among participants not infected with HIV (p=0.403). The prevalence of prevalent HBV infection was 55% in adults aged >50 years old, and 11% in persons under 20 years. In multivariable analysis, older age, HIV status and serologic syphilis were significantly associated with prevalent HBV infection. Transfusion status and receipt of injections were not significantly associated with HBV infection. Contrary to expectations that HBV exposure in Uganda occurred chiefly during childhood, prevalent HBV infection was found to increase with age and was associated sexually transmitted diseases (HIV and syphilis.) Therefore vaccination against HBV, particularly susceptible adults with HIV or at risk of HIV/STDs should be a priority.en_US
dc.identifier.citationStabinski, L., Reynolds, S. J., Ocama, P., Laeyendecker, O., Serwadda, D., Gray, R. H., ... & Kirk, G. D. (2011). Hepatitis B virus and sexual behavior in Rakai, Uganda. Journal of medical virology, 83(5), 796-800. doi:10.1002/jmv.22051.en_US
dc.identifier.other10.1002/jmv.22051.
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/3071
dc.language.isoenen_US
dc.publisherJournal of medical virologyen_US
dc.subjectHepatitis B virus HBVen_US
dc.subjectHIVen_US
dc.subjectSexual transmissionen_US
dc.subjectUgandaen_US
dc.subjectAfricaen_US
dc.titleHepatitis B virus and sexual behavior in Rakai, Ugandaen_US
dc.typeArticleen_US
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