Environmental surveillance detects circulating vaccine-derived poliovirus type 2 that was undetected by acute flaccid paralysis surveillance in 2021 in Uganda

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dc.contributor.authorTushabe, Phionah
dc.contributor.authorBwogi, Josephine
dc.contributor.authorEliku, James Peter
dc.contributor.authorAine, Francis
dc.contributor.authorBirungi, Molly
dc.contributor.authorGaizi, Joseph
dc.contributor.authorNakabazzi, Lucy
dc.contributor.authorKabaliisa, Theopista
dc.contributor.authorTuryahabwe, Irene
dc.contributor.authorNamuwulya, Prossy
dc.contributor.authorNanteza, Mary Bridget
dc.contributor.authorBukenya, Henry
dc.contributor.authorKanyesigye, Christopher
dc.contributor.authorKatushabe, Edson
dc.contributor.authorAmpeire, Immaculate
dc.contributor.authorKisakye, Annet
dc.contributor.authorBakamutumaho, Barnabas
dc.date.accessioned2025-03-09T16:28:21Z
dc.date.available2025-03-09T16:28:21Z
dc.date.issued2021
dc.description.abstractThe success of the global polio eradication initiative is threatened by the genetic instability of the oral polio vaccine, which can result in the emergence of pathogenic vaccine-derived polioviruses following prolonged replication in the guts of individuals with primary immune deficiencies or in communities with low vaccination coverage. Through environmental surveillance, circulating vaccine-derived poliovirus type 2 was detected in Uganda in the absence of detection by acute flaccid paralysis (AFP) surveillance. This underscores the sensitivity of environmental surveillance and emphasizes its usefulness in supplementing AFP surveillance for poliovirus infections in the race towards global polio eradication.
dc.identifier.citationTushabe, P., Bwogi, J., Eliku, J. P., Aine, F., Birungi, M., Gaizi, J., ... & Byabamazima, C. R. (2023). Environmental surveillance detects circulating vaccine-derived poliovirus type 2 that was undetected by acute flaccid paralysis surveillance in 2021 in Uganda. Archives of Virology, 168(5), 140.
dc.identifier.urihttps://doi.org/10.1007/s00705-023-05759-w
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/10088
dc.language.isoen
dc.publisherArchives of Virology
dc.titleEnvironmental surveillance detects circulating vaccine-derived poliovirus type 2 that was undetected by acute flaccid paralysis surveillance in 2021 in Uganda
dc.typeArticle
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