The impact of helminths on the response to immunization and on the incidence of infection and disease in childhood in Uganda: design of a randomized, double-blind, placebo-controlled, factorial trial of deworming interventions delivered in pregnancy and early childhood [ISRCTN32849447]

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dc.contributor.authorElliotta, Alison M.
dc.contributor.authorKizza, Moses
dc.contributor.authorQuigley, Maria A.
dc.contributor.authorNdibazza, Juliet
dc.contributor.authorNampijja, Margaret
dc.contributor.authorMuhangi, Lawrence
dc.contributor.authorMorison, Linda
dc.contributor.authorNamujju, Proscovia B.
dc.contributor.authorMuwanga, Moses
dc.contributor.authorKabatereine, Narcis
dc.contributor.authorWhitworth, James A. G.
dc.date.accessioned2022-01-30T15:58:04Z
dc.date.available2022-01-30T15:58:04Z
dc.date.issued2007
dc.description.abstractHelminths have profound effects on the immune response, allowing long-term survival of parasites with minimal damage to the host. Some of these effects “spill-over”, altering responses to non-helminth antigens or allergens. It is suggested that this may lead to impaired responses to immunizations and infections, while conferring benefits against inflammatory responses in allergic and autoimmune disease. These effects might develop in utero, through exposure to maternal helminth infections, or through direct exposure in later life. Purpose To determine the effects of helminths and their treatment in pregnancy and in young children on immunological and disease outcomes in childhood.en_US
dc.identifier.citationElliott, A. M., Kizza, M., Quigley, M. A., Ndibazza, J., Nampijja, M., Muhangi, L., ... & Whitwortha, J. A. (2007). The impact of helminths on the response to immunization and on the incidence of infection and disease in childhood in Uganda: design of a randomized, double-blind, placebo-controlled, factorial trial of deworming interventions delivered in pregnancy and early childhood [ISRCTN32849447]. Clinical trials, 4(1), 42-57. doi:10.1177/1740774506075248en_US
dc.identifier.other10.1177/1740774506075248
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1628
dc.language.isoenen_US
dc.publisherClinical trialsen_US
dc.subjectHelminthsen_US
dc.subjectImmunizationen_US
dc.subjectInfectionen_US
dc.subjectDiseaseen_US
dc.subjectChildhooden_US
dc.subjectDewormingen_US
dc.subjectPregnancyen_US
dc.titleThe impact of helminths on the response to immunization and on the incidence of infection and disease in childhood in Uganda: design of a randomized, double-blind, placebo-controlled, factorial trial of deworming interventions delivered in pregnancy and early childhood [ISRCTN32849447]en_US
dc.typeArticleen_US
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