Symptomatic Hyperlactatemia Associated with Nucleoside Analogue Reverse-Transcriptase Inhibitor Use in HIV-Infected Patients: A Report of 24 Cases in a Resource-Limited Setting (Uganda)
Loading...
Date
2007
Journal Title
Journal ISSN
Volume Title
Publisher
Clinical infectious diseases
Abstract
We describe 24 Ugandan patients with human immunodeficiency
virus infection who developed symptomatic hyperlactatemia
associated with the use of nucleoside analogues.
All patients were receiving combination therapy that contained
stavudine. The median serum lactate level was 6.6
mmol/L. All patients had their antiretroviral treatment regimen
discontinued. Hospital admission was required for 5
patients. Five patients died.
Description
Keywords
Symptomatic Hyperlactatemia, Nucleoside Analogue Reverse-Transcriptase, HIV-Infected Patients
Citation
Songa, P. M., Castelnuovo, B., Mugasha, E. B., Ocama, P., & Kambugu, A. (2007). Symptomatic hyperlactatemia associated with nucleoside analogue reverse-transcriptase inhibitor use in HIV-infected patients: a report of 24 cases in a resource-limited setting (Uganda). Clinical infectious diseases, 45(4), 514-517. DOI: 10.1086/520023