Sex and HIV Differences in Preserved Ratio Impaired Spirometry (PRISm) Among Ugandans Postpneumonia

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dc.contributor.authorAbelman, Rebecca A
dc.contributor.authorFitzpatrick, Jessica
dc.contributor.authorByanova, Katerina L
dc.contributor.authorZawedde, Josephine
dc.contributor.authorSanyu, Ingvar
dc.contributor.authorByanyima, Patrick
dc.contributor.authorMusisi, Emmanuel
dc.contributor.authorHsieh, Jenny
dc.contributor.authorZhang, Michelle
dc.contributor.authorBranchini, Jake
dc.contributor.authorSessolo, Abdul
dc.contributor.authorHunt, Peter W
dc.contributor.authorLalitha, Rejani
dc.contributor.authorDavis, J Lucian
dc.contributor.authorCrothers, Kristina
dc.contributor.authorWorodria, William
dc.contributor.authorHuang, Laurence
dc.date.accessioned2024-03-12T13:40:12Z
dc.date.available2024-03-12T13:40:12Z
dc.date.issued2024-03
dc.description.abstractPreserved ratio impaired spirometry (PRISm), defined as a normal ratio of forced expiratory volume in 1 second (FEV ) to forced vital capacity (≥0.70) with low FEV (<80% predicted), has been associated with increased mortality in the general population. Female sex has been associated with increased odds of PRISm in people without HIV. People with HIV (PWH) are at increased risk for lung function abnormalities, but whether HIV modifies the effect of sex on PRISm development is largely unknown. Adults with and without HIV underwent baseline followed by serial spirometry after completing therapy for pneumonia, predominantly tuberculosis (TB), in Kampala, Uganda. Using generalized estimating equations adjusted for age, body mass index, smoking, biomass fuel exposure, HIV, and TB status, we compared individuals with PRISm with those with normal spirometry. These models were stratified by HIV status. Of 339 baseline participants, 153 (45%) were women; 129 (38%) had HIV, of whom 53% were women. Overall, 105/339 participants (31%) had PRISm at baseline. HIV was associated with lower odds of PRISm (adjusted odds ratio [aOR], 0.38; 95% CI, 0.21-0.68; = .001). Female sex trended toward increased odds of PRISm among all participants (aOR, 1.65; 95% CI, 0.99-2.75; = .052). The association between female sex and PRISm tended to be stronger among PWH (aOR, 3.16; 95% CI, 1.14-8.76; = .03) than among those without HIV (aOR, 1.34; 95% CI, 0.73-2.45; = .34); this study was underpowered to detect an HIV-sex interaction of this magnitude ( = .30). Among Ugandan adults who recovered from pneumonia, female sex was associated with increased odds and HIV with decreased odds of PRISm, suggesting independent sex and HIV effects on PRISm pathogenesis.en_US
dc.identifier.citationAbelman, Rebecca A., Jessica Fitzpatrick, Katerina L. Byanova, et al. 'Sex and HIV Differences in Preserved Ratio Impaired Spirometry (PRISm) among Ugandans Postpneumonia', Open Forum Infectious Diseases, vol. 11/no. 3, (2024), pp. ofae033.en_US
dc.identifier.issnISSN 2328-8957
dc.identifier.issnEISSN 2328-8957
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/9434
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.subjectHIV; preserved ratio impaired spirometry; sex differences; tuberculosisen_US
dc.titleSex and HIV Differences in Preserved Ratio Impaired Spirometry (PRISm) Among Ugandans Postpneumoniaen_US
dc.typeArticleen_US
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