Three year survival among patients with aids-related Kaposi sarcoma treated with chemotherapy and combination antiretroviral therapy at Moi teaching and referral hospital, Kenya

Simple item page
dc.contributor.authorBusakhala, Naftali
dc.contributor.authorKigen, Gabriel
dc.contributor.authorWaako, Paul
dc.contributor.authorStrother, Matthew R.
dc.contributor.authorChite, Fredrick
dc.contributor.authorLoehrer, Patrick
dc.date.accessioned2021-12-13T06:49:44Z
dc.date.available2021-12-13T06:49:44Z
dc.date.issued2019
dc.description.abstractAIDS-related Kaposi sarcoma (AIDS-KS), a common malignancy in Kenya is associated with high morbidity and mortality. AIDS-KS is treated using bleomycin and vincristine (BV) plus or minus doxorubicin in most low resource settings, with response rates ranging from 24.8 to 87%. Survival in low resource settings has not been well documented. We report the three-year survival in a cohort of seventy patients referred to Moi Teaching and Referral Hospital (MTRH). Methods: Study participants are part of a randomized phase IIA trial on the use of gemcitabine compared to bleomycin plus vincristine for the treatment of Kaposi sarcoma after combination antiretroviral therapy (cART) in Western Kenya. All patients were followed for three years in MTRH. Survival was determined by three monthly physical examination and analysed using Kaplan-Meier method, while possible determinants of survival such as baseline characteristics, type of chemotherapy, initial CD4 counts, age at enrolment, gender and early response to chemotherapy were analysed using univariate and multivariate Cox regression.en_US
dc.identifier.citationBusakhala, N., Kigen, G., Waako, P., Strother, R. M., Chite, F., & Loehrer, P. (2019). Three year survival among patients with aids-related Kaposi sarcoma treated with chemotherapy and combination antiretroviral therapy at Moi teaching and referral hospital, Kenya. Infectious agents and cancer, 14(1), 1-8.doi.10.1186/s13027-019-0242-9en_US
dc.identifier.other10.1186/s13027-019-0242-9
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/383
dc.language.isoenen_US
dc.publisherInfectious agents and canceren_US
dc.subjectAIDS-related Kaposien_US
dc.subjectsarcomaen_US
dc.subjectSurvivalen_US
dc.subjectKenyaen_US
dc.titleThree year survival among patients with aids-related Kaposi sarcoma treated with chemotherapy and combination antiretroviral therapy at Moi teaching and referral hospital, Kenyaen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Three year survival among patients with.pdf
Size:
826.88 KB
Format:
Adobe Portable Document Format
Description:
Article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Medical and Health Sciences