Isolation of Genetically Diverse Marburg Viruses from Egyptian Fruit Bats

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dc.contributor.authorTowner, Jonathan S.
dc.contributor.authorAmman, Brian R.
dc.contributor.authorSealy, Tara K.
dc.contributor.authorCarroll, Serena A. Reeder
dc.contributor.authorComer, James A.
dc.contributor.authorKemp, Alan
dc.contributor.authorSwanepoel, Robert
dc.contributor.authorPaddock, Christopher D.
dc.contributor.authorBalinandi, Stephen
dc.contributor.authorKhristova, Marina L.
dc.contributor.authorFormenty, Pierre B. H.
dc.contributor.authorAlbarino, Cesar G.
dc.contributor.authorMiller, David M.
dc.contributor.authorReed, Zachary D.
dc.contributor.authorKayiwa, John T.
dc.contributor.authorMills, James N.
dc.contributor.authorCannon, Deborah L.
dc.contributor.authorGreer, Patricia W.
dc.contributor.authorByaruhanga, Emmanuel
dc.contributor.authorFarnon, Eileen C.
dc.contributor.authorAtimnedi, Patrick
dc.contributor.authorOkware, Samuel
dc.contributor.authorMbidde, Edward Katongole
dc.contributor.authorDowning, Robert
dc.contributor.authorTappero, Jordan W.
dc.contributor.authorZaki, Sherif R.
dc.contributor.authorKsiazek, Thomas G.
dc.contributor.authorNichol, Stuart T.
dc.contributor.authorRollin, Pierre E.
dc.date.accessioned2022-01-24T15:52:19Z
dc.date.available2022-01-24T15:52:19Z
dc.date.issued2009
dc.description.abstractIn July and September 2007, miners working in Kitaka Cave, Uganda, were diagnosed with Marburg hemorrhagic fever. The likely source of infection in the cave was Egyptian fruit bats (Rousettus aegyptiacus) based on detection of Marburg virus RNA in 31/611 (5.1%) bats, virus-specific antibody in bat sera, and isolation of genetically diverse virus from bat tissues. The virus isolates were collected nine months apart, demonstrating long-term virus circulation. The bat colony was estimated to be over 100,000 animals using mark and re-capture methods, predicting the presence of over 5,000 virus-infected bats. The genetically diverse virus genome sequences from bats and miners closely matched. These data indicate common Egyptian fruit bats can represent a major natural reservoir and source of Marburg virus with potential for spillover into humans.en_US
dc.identifier.citationTowner, J. S., Amman, B. R., Sealy, T. K., Carroll, S. A. R., Comer, J. A., Kemp, A., ... & Rollin, P. E. (2009). Isolation of genetically diverse Marburg viruses from Egyptian fruit bats. PLoS pathogens, 5(7), e1000536.https://doi.org/10.1371/journal.ppat.1000536en_US
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1505
dc.language.isoenen_US
dc.publisherPLoS pathogensen_US
dc.titleIsolation of Genetically Diverse Marburg Viruses from Egyptian Fruit Batsen_US
dc.typeArticleen_US
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