Uptake of hepatitis B-HIV co-infection screening and management in a resource limited setting
Loading...
Date
2018
Journal Title
Journal ISSN
Volume Title
Publisher
Hepatology, Medicine and Policy
Abstract
WHO hepatitis B guidelines recommend testing all new HIV patients, treating them accordingly
or providing immunization. At the Infectious Diseases Institute (IDI) following an audit done in 2012, only 46%
patients had been screened for hepatitis B with variable management plans therefore new internal guidelines
were implemented. This study describes the uptake of hepatitis B screening and management of patients
with hepatitis B and HIV con-infection after the implementation.
Methods: Data included for all HIV positive patients in care at IDI by October 2015. Data are expressed as median with
interquartile range (IQR) and percentages were compared using the chi square test. Statistical analysis was performed
using STATA version 13. The IDI laboratory upper limit of normal for alanine aminotransferase (ALT) and aspartate
aminotransferase (ASTs) was 40 IU/ml.
Results: Number of hepatitis B screening tests increased from 800 by 2012 to 1400 in 2015. By 2015 8042/8604(93.5%)
patients had been screened for hepatitis B. Overall hepatitis B positive were 359 (4.6%). 166 (81.4%) hepatitis B positives
were switched to a tenofovir (TDF) containing regimen.
Conclusion: Our study confirms the importance of screening for hepatitis B and of using ART regimens containing
tenofovir in hepatitis B co-infected patients. Whilst our program has made improvements in care still 18.6% of patients
with hepatitis B were not on tenofovir regimens, 98.1% had no hepatitis B viral loads done. Clinicians should recognize
the potential for hepatitis B in HIV positive patients and the importance of early diagnosis and treatment to ensure
optimal management of cases and follow up.
Description
Keywords
Hepatitis B, HIV/AIDs, Resource limited setting
Citation
Rachel, M., Barbara, C., Murphy, C., Komujuni, C., Nyakato, P., Ocama, P., ... & Ratanshi, R. P. (2018). Uptake of hepatitis B-HIV co-infection screening and management in a resource limited setting. Hepatology, Medicine and Policy, 3(1), 1-7. DOI 10.1186/s41124-017-0030-3