Historical Elimination of Onchocerciasis from Victoria Nile Focus in Central Uganda Verified Using WHO Criteria

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dc.contributor.authorKatabarwa, Moses N.
dc.contributor.authorHabomugisha, Peace
dc.contributor.authorKhainza, Annet
dc.contributor.authorOguttu, David W.
dc.contributor.authorByamukama, Edson
dc.contributor.authorKatamanywa, James
dc.contributor.authorNahabwe, Christine
dc.contributor.authorNgabirano, Monica
dc.contributor.authorAkampurira, Paul
dc.contributor.authorBernard, Lauri
dc.contributor.authorUnnasch, Thomas R.
dc.contributor.authorRichards, Frank
dc.date.accessioned2022-08-22T20:51:38Z
dc.date.available2022-08-22T20:51:38Z
dc.date.issued2020
dc.description.abstractUganda has verified elimination of seven onchocerciasis foci since 2007 when the nationwide onchocerciasis elimination policy was launched. However, the Victoria Nile focus (which was eliminated in the early 1970s) had not been verified. The objective of this study was to verify this focus to the WHO verification guidelines and bring it in line with recently eliminated foci. Vector control with dichlorodiphenyltrichloroethane was the main intervention used at the Victoria Nile from the 1950s to the 1970s. Historical fly collection sites along River Nile were identified for recent fly collection. Relevant health workers near the sites were trained to supervise fly collection activity. With support from communities, fly collectors were identified, trained, and equipped to collect Simulium flies for at least a year. A total of 854 Simulium flies were collected and analyzed by polymerase chain reaction to detect Onchocerca volvulus DNA. The communities and their leaders provided consent for the collection of dry blood spots (DBS) from children younger than 10 years for investigation of recent exposure to the disease.A total of 2,953DBSwere collected and analyzed by OV16 ELISA to detect the presence of IgG4 antibodies recognizing the OV16 antigen. The results showed that none of the flies carried O. volvulus DNA. Similarly, all the children were OV16 negative, showing no exposure to onchocerciasis. All the flies collected were identified as Simulium adersi, which is not a known vector for O. volvulus. The results confirmed that onchocerciasis and its vector Simulium damnosum had been eliminated in the Victoria Nile focus.en_US
dc.identifier.citationKatabarwa, M. N., Habomugisha, P., Khainza, A., Oguttu, D. W., Byamukama, E., Katamanywa, J., ... & Richards, F. (2020). Historical Elimination of Onchocerciasis from Victoria Nile Focus in Central Uganda Verified Using WHO Criteria. The American journal of tropical medicine and hygiene, 102(6), 1411. doi:10.4269/ajtmh.20-0064en_US
dc.identifier.other10.4269/ajtmh.20-0064
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/4377
dc.language.isoenen_US
dc.publisherThe American journal of tropical medicine and hygieneen_US
dc.subjectOnchocerciasisen_US
dc.subjectVictoria Nile Focusen_US
dc.subjectCentral Ugandaen_US
dc.subjectWHO Criteriaen_US
dc.titleHistorical Elimination of Onchocerciasis from Victoria Nile Focus in Central Uganda Verified Using WHO Criteriaen_US
dc.typeArticleen_US
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