Vitamin E and Donepezil for the Treatment of Mild Cognitive Impairment

dc.contributor.authorPetersen, Ronald C.
dc.contributor.authorThomas, Ronald G.
dc.contributor.authorKaye, Jeffrey
dc.contributor.authorSano, Mary
dc.date.accessioned2024-12-15T19:23:41Z
dc.date.available2024-12-15T19:23:41Z
dc.date.issued2005-04-13
dc.description.abstractMild cognitive impairment is a transitional state between the cognitive changes of normal aging and early Alzheimer’s disease. In a double-blind study, we evaluated subjects with the amnestic subtype of mild cognitive impairment. Subjects were randomly assigned to receive 2000 IU of vitamin E daily, 10 mg of donepezil daily, or placebo for three years. The primary outcome was clinically possible or probable Alzheimer’s disease; secondary outcomes were cognition and function.
dc.identifier.citationPetersen, R. C., Thomas, R. G., Grundman, M., Bennett, D., Doody, R., Ferris, S., ... & Thal, L. J. (2005). Vitamin E and donepezil for the treatment of mild cognitive impairment. New England Journal of Medicine, 352(23), 2379-2388.
dc.identifier.othervol. 352 no. 23
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/9723
dc.language.isoen
dc.publisherNew England Journal of Medicine
dc.titleVitamin E and Donepezil for the Treatment of Mild Cognitive Impairment
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