Immune Reconstitution Inflammatory Syndrome among Adolescents: A Report of Cases in a Resource-Limited Setting (Uganda)
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Date
2010
Journal Title
Journal ISSN
Volume Title
Publisher
Southern African Journal of HIV Medicine
Abstract
The immune reconstitution inflammatory syndrome
(IRIS) is a frequent early complication of antiretroviral
therapy (ART), particularly in patients who commence
ART with low CD4 counts and established opportunistic
infections. IRIS in HIV-infected patients results from
a pathological inflammatory response to pre-existing
infective, host or other antigens, alive or dead, causing
clinical deterioration after initiating ART.1 The most
common forms of IRIS occur in association with
mycobacterial and herpesvirus infections. Adolescents and young adults comprise an increasing
proportion of new HIV infections both in developing
and developed countries, and little is known regarding
HIV IRIS in this group. As the ART roll-out has gathered
pace since 2004 in resource-limited settings, adolescent
IRIS has emerged as a clinical challenge. We describe
adolescent/young adult patients who presented to our
clinic with IRIS events.
Description
Keywords
Immune Reconstitution Inflammatory Syndrome, Adolescents, Resource-Limited Setting, Uganda
Citation
Katusiime, C., Ocama, P., & Kambugu, A. (2010). Immune reconsitution inflammatory syndrome among adolescents: a report of cases in a resource-limited setting (Uganda). Southern African Journal of HIV Medicine, 11(2), 18-22.