HIV Incidence by Male Circumcision Status From the Population-Based HIV Impact Assessment Surveys—Eight Sub-Saharan African Countries, 2015–2017

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dc.contributor.authorHines, Jonas Z.
dc.contributor.authorSachathep, Karampreet
dc.contributor.authorPals, Sherri
dc.contributor.authorDavis, Stephanie M.
dc.contributor.authorToledo, Carlos
dc.contributor.authorBronson, Megan
dc.contributor.authorParekh, Bharat
dc.contributor.authorCarrasco, Maria
dc.contributor.authorXaba, Sinokuthemba
dc.contributor.authorMandisarisa, John
dc.contributor.authorKamobyi, Royd
dc.contributor.authorChituwo, Omega
dc.contributor.authorKirungi, Wilford L.
dc.contributor.authorAlamo, Stella
dc.contributor.authorKabuye, Geoffrey
dc.contributor.authorAwor, Anna Colletar
dc.contributor.authorMmbando, Susan
dc.contributor.authorSimbeye, Daimon
dc.contributor.authorAupokolo, Mekondjo A.
dc.contributor.authorZemburuka, Brigitte
dc.contributor.authorNyirenda, Rose
dc.contributor.authorMsungama, Wezi
dc.contributor.authorTarumbiswa, Tapiwa
dc.contributor.authorManda, Robert
dc.contributor.authorBiribonwoha, Harriet Nuwagaba
dc.contributor.authorKiggundu, Valerian
dc.contributor.authorThomas, Anne G.
dc.contributor.authorVoetsch, Andrew C.
dc.contributor.authorWilliams, Dan B.
dc.date.accessioned2022-03-21T15:00:31Z
dc.date.available2022-03-21T15:00:31Z
dc.date.issued2021
dc.description.abstractConducting HIV surveys in resource-limited settings is challenging because of logistics, limited availability of trained personnel, and complexity of testing. We described the procedures and systems deemed critical to ensure high-quality laboratory data in the population-based HIV impact assessments and large-scale household surveys.Laboratory professionals were engaged in every stage of the surveys, including protocol development, site assessments, procurement, training, quality assurance, monitoring, analysis, and reporting writing. A tiered network of household, satellite laboratories, and central laboratories, accompanied with trainings, optimized process for blood specimen collection, storage, transport, and real-time monitoring of specimen quality, and test results at each level proved critical in maintaining specimen integrity and high-quality testing. A plausibility review of aggregate merged data was conducted to confirm associations between key variables as a final quality check for quality of laboratory results.Overall, we conducted a hands-on training for 3355 survey staff across 13 surveys, with 160–387 personnel trained per survey on biomarker processes. Extensive training and monitoring demonstrated that overall, 99% of specimens had adequate volume and 99.8% had no hemolysis, indicating high quality. We implemented quality control and proficiency testing for testing, resolved discrepancies, verified >300 Pima CD4 instruments, and monitored user errors. Aggregate data review for plausibility further confirmed the high quality of testing.Ongoing engagement of laboratory personnel to oversee processes at all levels of the surveys is critical for successful national surveys. High-quality population-based HIV impact assessments laboratory data ensured reliable results and demonstrated the impact of HIV programs in 13 countries.en_US
dc.identifier.citationHines, J. Z., Sachathep, K., Pals, S., Davis, S. M., Toledo, C., Bronson, M., ... & Williams, D. B. (2021). HIV incidence by male circumcision status from the Population-Based HIV Impact Assessment Surveys—Eight sub-Saharan African countries, 2015–2017. JAIDS Journal of Acquired Immune Deficiency Syndromes, 87, S89-S96.doi: 10.1097/QAI.0000000000002702en_US
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/2872
dc.language.isoenen_US
dc.publisherJAIDS Journal of Acquired Immune Deficiency Syndromesen_US
dc.subjectmale circumcision, HIV, Africa, incidenceen_US
dc.titleHIV Incidence by Male Circumcision Status From the Population-Based HIV Impact Assessment Surveys—Eight Sub-Saharan African Countries, 2015–2017en_US
dc.typeArticleen_US
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