Tabletized Supramolecular Assemblies for Sublingual Peptide Immunization
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Date
2021
Journal Title
Journal ISSN
Volume Title
Publisher
Advanced healthcare materials
Abstract
Widespread vaccination is essential to global health. Significant barriers exist
to improving vaccine coverage in lower- and middle-income countries,
including the costly requirements for cold-chain distribution and trained
medical personnel to administer the vaccines. A heat-stable and highly porous
tablet vaccine that can be administered sublingually via simple dissolution
under the tongue is described. SIMPL tablet vaccines (Supramolecular
IMmunization with Peptides subLingually) are produced by freeze-drying a
mixture of self-assembling peptide-polymer nanofibers, sugars, and adjuvant.
Sublingual immunization with SIMPL tablets raises antibody responses
against both a model epitope from ovalbumin and a clinically relevant epitope
from Mycobacterium tuberculosis. Further, sublingual antibody responses are
not diminished after heating the tablets for 1 week at 45 °C, in contrast to a
more conventional carrier vaccine (KLH). This approach directly addresses the
need for a heat-stable and easily deliverable vaccine to improve equity in
global vaccine coverage.
Description
Keywords
Tabletized Supramolecular, Sublingual Peptide Immunization
Citation
Kelly, S. H., Opolot, E. E., Wu, Y., Cossette, B., Varadhan, A. K., & Collier, J. H. (2021). Tabletized supramolecular assemblies for sublingual peptide immunization. Advanced healthcare materials, 10(6), 2001614. DOI: 10.1002/adhm.202001614