Evaluating Herbal Medicine for the Management of Herpes zoster in Human Immunodeficiency Virus-Infected Patients in Kampala, Uganda

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dc.contributor.authorHomsy, Jacques
dc.contributor.authorKatabira, Elly
dc.contributor.authorKabatesi, Donna
dc.contributor.authorMubiru, Francis
dc.contributor.authorKwamya, Luke
dc.contributor.authorTusaba, Christine
dc.contributor.authorKasolo, Scovia
dc.contributor.authorMwebe, Dominic
dc.contributor.authorSsentamu, Lutakome
dc.contributor.authorOkello, Matiya
dc.contributor.authorKing, Racheal
dc.date.accessioned2023-06-14T20:33:28Z
dc.date.available2023-06-14T20:33:28Z
dc.date.issued1999
dc.description.abstractThis study was carried out to evaluate the potential effectiveness of herbal treat- ments used for herpes zoster (HZ) by a great number of people living with acquired immuno- deficiency syndrome (PLWAs) in Uganda. Setting: Kampala, Uganda. Clinics of indigenous traditional healers, at the Department of Medicine of Mulago Hospital, Makerere University, and at The AIDS Support Organization (TASO) Clinic, providing primary care to people living with HIV and AIDS. Design, patients, and participants: Nonrandomized, nonplacebo controlled, observational study in two phases. Inclusion criteria included HIV seropositivity and a recent HZ attack. In phase 1, 52 patients were enrolled, treated, and followed for up to 3 months at three healers' clinics, and compared to 52 TASO Clinic controls receiving ambulatory care. Phase 2 was simi- lar in design to phase 1, but lasted longer (6-month follow-up) and involved 154 hospital out- patients treated with herbal medicine and 55 TASO controls. In both phases, healer patients were given herbal treatment according to healers' prescriptions, while controls received either symp- tomatic treatment or acyclovir. Results: Healer patients and controls experienced similar rates of resolution of their HZ at- tacks. Fewer healer patients than controls experienced superinfection in phase 1 (18% versus 42%, p < 0.02) and fewer healer patients showed keloid formation in either phase. This differ- ence was not statistically significant. In both phases, zoster-associated pain resolved substantially faster among healer patients with a higher degree of significance in phase 2 where the progression of pain over time could be seen because of the longer follow-up (phase 1: maximum p value (pmax) < Pmax < 0.02 at 1 month, Pmax < 0.005 at 2 months, p^ax < 0.0001 at 3 months). Conclusion: Herbal treatment is an important local and affordable primary care alternative for the management of HZ in HIV-infected patients in Uganda and similar settings.en_US
dc.identifier.citationHomsy, J., Katabira, E., Kabatesi, D., Mubiru, F., Kwamya, L., Tusaba, C., ... & King, R. (1999). Evaluating herbal medicine for the management of Herpes zoster in human immunodeficiency virus-infected patients in Kampala, Uganda. The Journal of Alternative and Complementary Medicine, 5(6), 553-565.en_US
dc.identifier.urihttps://www.liebertpub.com/doi/abs/10.1089/acm.1999.5.553?casa_token=qwiW61BkiGYAAAAA:EUlBFRvdyDSoND5rHV3_tTflCsEDEGtASVWH33fRJFDf_jN4c82qqPu492RByhi2NALEI_utvmnytMX3
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8929
dc.language.isoenen_US
dc.publisherThe Journal of Alternative and Complementary Medicine,en_US
dc.subjectHerbal Medicineen_US
dc.subjectManagementen_US
dc.subjectHerpes zosteren_US
dc.subjectHuman Immunodeficiency Virus-Infected Patientsen_US
dc.titleEvaluating Herbal Medicine for the Management of Herpes zoster in Human Immunodeficiency Virus-Infected Patients in Kampala, Ugandaen_US
dc.typeArticleen_US
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