Prevalence and Factors associated with Hypothyroidism in Children with Sickle Cell Anemia aged 6 months −17 years attending the Sickle Cell Clinic, Mulago Hospital, Uganda; a cross-sectional study

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dc.contributor.authorKaudha, Gloria
dc.contributor.authorPiloya, Thereza
dc.contributor.authorMusiime, Victor
dc.contributor.authorKuteesa, Mary Goretty
dc.contributor.authorNamugerwa, Shamimu
dc.contributor.authorOwomugisha, Gloria
dc.contributor.authorWachepa, Stella Alinafe
dc.contributor.authorLubwama, Sanyu Kirabo
dc.contributor.authorKiguli, Sarah
dc.contributor.authorTumwine, James K.
dc.date.accessioned2023-08-07T18:52:07Z
dc.date.available2023-08-07T18:52:07Z
dc.date.issued2023
dc.description.abstractHypothyroidism has been reported at a prevalence of 6% in children and adolescents with Sickle cell anemia. In this study, we determined the prevalence and factors associated with hypothyroidism among children with Sickle cell anemia attending the Sickle Cell Clinic, in Mulago hospital, Uganda. A cross-sectional study was conducted among children aged 6 months − 17 years with a confirmed diagnosis of Sickle Cell Anemia, with no prior diagnosis of hypothyroidism and in steady state attending the Sickle Cell Clinic in Mulago hospital. Data was collected using a structured questionnaire and a blood sample was used to measure thyroid stimulating hormone and free thyroxine. Of the 332 children enrolled, sixty (18.1%) participants had sub-clinical hypothyroidism (95% CI: 14.3 — 22.6). Factors associated with hypothyroidism included constipation [adjusted odds ratio: 3.1, 95% CI:1.0 — 9.0, p = 0.043] and male sex [adjusted odds ratio:2.0, 95% CI:1.1— 3.5, p = 0.025]. Approximately 1 in 5 children (18.1%) had sub-clinical hypothyroidism. Males and children who presented with constipation were more likely to have sub-clinical hypothyroidism.en_US
dc.identifier.citationKaudha, G., Piloya, T., Musiime, V., Kuteesa, M. G., Namugerwa, S., Owomugisha, G., ... & Tumwine, J. K. (2023). Prevalence and factors associated with hypothyroidism in children with sickle cell anemia aged 6 months− 17 years attending the Sickle Cell Clinic, Mulago Hospital, Uganda; a cross-sectional study. BMC Endocrine Disorders, 23(1), 1-9.https://doi.org/10.1186/s12902-023-01317-2en_US
dc.identifier.issn1472-6823
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/9114
dc.language.isoenen_US
dc.publisherBMC Endocrine Disordersen_US
dc.subjectHypothyroidismen_US
dc.subjectSickle cell anemiaen_US
dc.subjectConstipationen_US
dc.titlePrevalence and Factors associated with Hypothyroidism in Children with Sickle Cell Anemia aged 6 months −17 years attending the Sickle Cell Clinic, Mulago Hospital, Uganda; a cross-sectional studyen_US
dc.typeArticleen_US
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