Proportion of Deaths and Clinical Features in Bundibugyo Ebola Virus Infection, Uganda
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Date
2010
Journal Title
Journal ISSN
Volume Title
Publisher
Emerging infectious diseases
Abstract
Ebola hemorrhagic fever (EHF) is a severe disease
caused by several species of Ebolavirus (EBOV),
in the family Filoviridae. Before 2007, four species of
EBOV had been identifi ed; 2 of these, Zaire ebolavirus
and Sudan ebolavirus, have caused large human outbreaks
in Africa, with proportion of deaths ≈80%–90% and 50%,
respectively (1–5). Large outbreaks are associated with
person-to-person transmission after the virus is introduced
into humans from a zoonotic reservoir. Data suggest that
this reservoir may be fruit bats (6,7). During outbreaks of
EHF, the virus is commonly transmitted through direct
contact with infected persons or their bodily fl uids (8–11).
The onset of EHF is associated with nonspecifi c signs and
symptoms, including fever, myalgias, headache, abdominal
pain, nausea, vomiting, and diarrhea; at later stages of
disease, overt hemorrhage has been reported in ≈45% of
cases (12).
Bundibugyo District is located in western Uganda,
which borders the Democratic Republic of Congo. After
reports of a mysterious illness in Bundibugyo District, the
presence of a novel, fi fth EBOV virus species, Bundibugyo
ebolavirus (BEBOV), was identifi ed in diagnostic samples
submitted to the Centers for Disease Control and Prevention
(CDC), Atlanta, Georgia, USA, in November 2007 (13). In
response to detection of EBOV, an international outbreak
response was initiated. In this report, we summarize fi ndings
of laboratory-confi rmed cases of BEBOV infection.
Description
Keywords
Deaths, Clinical Features, Bundibugyo Ebola Virus Infection, Uganda
Citation
MacNeil, A., Farnon, E. C., Wamala, J., Okware, S., Cannon, D. L., Reed, Z., ... & Rollin, P. E. (2010). Proportion of deaths and clinical features in Bundibugyo Ebola virus infection, Uganda. Emerging infectious diseases, 16(12), 1969. DOI: 10.3201/eid1612.100627