Epidemiology of adverse drug reactions to antihypertensive, antithrombotic and antidiabetic medications among adult inpatients at a National Referral Hospital, Uganda

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dc.contributor.authorKuteesa, Jonathan
dc.contributor.authorNasasira, Marble
dc.contributor.authorKiguba, Ronald
dc.date.accessioned2025-06-23T10:16:10Z
dc.date.available2025-06-23T10:16:10Z
dc.date.issued2023-08-08
dc.description.abstractIntroduction Treatment for hypertension, thrombosis and type 2 diabetes mellitus is long term and usually requires a combination of drugs which increases the risk of adverse drug reactions (ADRs). This study aimed to establish the prevalence at admission, incidence during hospitalization and characteristics of ADRs linked to antihypertensive, antithrombotic and antidiabetic drugs among adult inpatients in Uganda. Methods We conducted a secondary analysis of data from a previously assembled prospective cohort study in Uganda’s Mulago National Referral Hospital. We reviewed the files of inpatients who received antihypertensive, antithrombotic and/or antidiabetic medications prior to and/or during hospitalization. The modified Schumock and Thornton Preventability Scale, the Division of AIDS Table for Grading the Severity of Adult and Paediatric Adverse Events and the World Health Organization – Uppsala Monitoring Centre seriousness criteria were used to characterize the ADRs. Results More than a quarter (27%, 42/155) of the inpatients experienced an ADR at admission or during hospitalization. The point prevalence of ADRs at admission was 8% (13/155) and the incidence of ADRs during hospitalization was 23% (36/155). Forty-one percent (35/86) of the ADRs were serious and the majority (59%, 51/86) were preventable. Conclusion One in 13 inpatients experienced an ADR on admission and one in four experienced an ADR that developed during hospitalization. Clinicians ought to prescribe medicines with lower ADR risk profile for cardiovascular and/or diabetic patients whenever possible.
dc.identifier.citationJonathan Kuteesa, Marble Nasasira & Ronald Kiguba (2024) Epidemiology of adverse drug reactions to antihypertensive, antithrombotic and antidiabetic medications among adult inpatients at a National Referral Hospital, Uganda, Expert Opinion on Drug Safety, 23:1, 129-136, DOI: 10.1080/14740338.2023.2244421
dc.identifier.doi10.1080/14740338.2023.2244421
dc.identifier.issn1474-0338
dc.identifier.issn1744-764X
dc.identifier.urihttps://doi.org/10.1080/14740338.2023.2244421
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/11881
dc.language.isoen
dc.publisherInforma UK Limited
dc.relation.ispartofExpert Opinion on Drug Safety
dc.titleEpidemiology of adverse drug reactions to antihypertensive, antithrombotic and antidiabetic medications among adult inpatients at a National Referral Hospital, Uganda
dc.typejournal-article
oaire.citation.issue1
oaire.citation.volume23
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