Hematological Reference Ranges among Healthy Ugandans
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Date
1995
Journal Title
Journal ISSN
Volume Title
Publisher
Clinical Diagnostic Laboratory Immunology
Abstract
An estimated 8 million individuals living in sub-Saharan Africa (including Uganda) are infected with the human immunodeficiency
virus (HIV) (2). Infection with HIV results in progressive generalized immune suppression due predominantly
to cytopathic effects of HIV type 1 (HIV-1) on CD41 T-helper–T-inducer lymphocytes (6). HIV also suppresses normal
hematopoiesis and is associated with a broad spectrum of hematologic abnormalities. Measurements of the peripheral
blood absolute CD4 cell count (ACD4), CD4 percentage (%CD4), and CD4/CD8 ratio have been found to be useful
surrogates for determining the risk of progression of HIV infection and are extensively used in observational studies and
AIDS clinical trials (7). Many AIDS-related research studies are being conducted in
Uganda and other African nations with a high prevalence of HIV infection. Because of the lack of normal reference ranges
for hematological parameters in healthy subjects, many investigators interpret their data using normal values derived from
populations in Europe and the United States. There is a need to establish appropriate normal reference values for hematologic
parameters in African populations. In this report, we describe hematologic reference ranges obtained by studying
183 symptom-free HIV-seronegative Ugandans. (Results of this investigation were presented at the Eighth
International Conference on AIDS in Africa, Marrakesh, Morocco, December 1993.)
Description
Keywords
human immunodeficiency virus, hematopoiesis, Ugandans
Citation
Tugume, S. B., Piwowar, E. M., Lutalo, T. O. M., Mugyenyi, P. N., Grant, R. M., Mangeni, F. W., ... & Katongole-Mbidde, E. (1995). Hematological reference ranges among healthy Ugandans. Clinical Diagnostic Laboratory Immunology, 2(2), 233-235.