Evaluation of effectiveness and safety of Subolesin anti-tick vaccine in Ugandan multi-site field trial

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dc.contributor.authorKabi, Fredrick
dc.contributor.authorMarinela, Contreras
dc.contributor.authorSemakula, Jimmy
dc.contributor.authorMartaSánchez-Sánchez
dc.contributor.authorClara, Muñoz-Hernández
dc.contributor.authorMugerwa, Swidiq
dc.contributor.authorKasaija, Paul
dc.contributor.authorKirunda, Halid
dc.contributor.authorGabrieladela, Fuente
dc.contributor.authorRuben, Fernandez-Melgar
dc.contributor.authorMarta, Rafael
dc.contributor.authorIsabel, G. Fernández de Mera
dc.contributor.authorMatovu, Moses
dc.contributor.authorKyakuwa, Ivan
dc.contributor.authorDhikusooka, Moses
dc.contributor.authorNsereko, Godfrey
dc.contributor.authorBoma, Paul
dc.contributor.authorBugeza, James
dc.contributor.authorMwesigwa, Moses
dc.contributor.authorNamukasa, Agnes
dc.contributor.authorObonyo, Philip
dc.contributor.authorSsekabunga, Nicholas
dc.contributor.authorAdyero, Okeny E.
dc.contributor.authorRutaisire, Justus
dc.contributor.authorChristian, Gortazar
dc.contributor.authorJosé de la Fuente
dc.date.accessioned2025-01-27T17:03:57Z
dc.date.available2025-01-27T17:03:57Z
dc.date.issued2024
dc.description.abstractVaccines are the most effective and sustainable intervention to control ticks and tick-borne disease (TBD). Using a personalized vaccine design based on regional tick genotypes, a Rhipicephalus appendiculatus Subolesin protective antigen was used in a field trial evaluating tick vaccine efficacy, effectiveness, and safety in cattle infested with multiple tick species in different Ugandan agro ecological zones. Vaccination with SUB was safe with a protective capacity against anemia and infection, and reduced the number of infested cattle, tick fitness (feeding and reproduction)with vaccine effectivenessagainstmultipletickspeciesbetween93.2%at167-196dayspost-vaccination(dpv)and 61.4% at 251–327 dpv. Total integrated vaccine efficacy/effectiveness was estimated as 98.8%. The Subolesin-based vaccine is protective against multiple cattle tick infestations under field conditions in Uganda. These results support registration and commercialization of the vaccine to reduce tick populations and associated risks for human and animal TBD and chemical acaracides in Uganda.
dc.identifier.citationKabi, F., Contreras, M., Semakula, J., Sánchez-Sánchez, M., Muñoz-Hernández, C., & Mugerwa, S. Evaluation of effectiveness and safety of Subolesin anti-tick vaccine in Ugandan multi-site field trial. NPJ Vaccines. 2024; 9: 174. https://doi.org/10.1038/s41541-024-00966-1
dc.identifier.urihttps://doi.org/10.1038/s41541-024-00966-1
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/9867
dc.language.isoen
dc.publisherNPJ Vaccines
dc.titleEvaluation of effectiveness and safety of Subolesin anti-tick vaccine in Ugandan multi-site field trial
dc.typeArticle
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