HPV types, HIV and invasive cervical carcinoma risk in Kampala, Uganda: a case-control study

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dc.contributor.authorOdida, Michael
dc.contributor.authorSandin, Sven
dc.contributor.authorMirembe, Florence
dc.contributor.authorKleter, Bernhard
dc.contributor.authorQuint, Wim
dc.contributor.authorWeiderpass, Elisabete
dc.date.accessioned2022-01-21T19:22:00Z
dc.date.available2022-01-21T19:22:00Z
dc.date.issued2018
dc.description.abstractWhile the association of human papillomavirus (HPV) with cervical cancer is well established, the influence of HIV on the risk of this disease in sub-Saharan Africa remains unclear. To assess the risk of invasive cervical carcinoma (ICC) associated with HIV and HPV types, a hospital-based case-control study was performed between September 2004 and December 2006 in Kampala, Uganda. Incident cases of histologically-confirmed ICC (N=316) and control women (N=314), who were visitors or care-takers of ICC cases in the hospital, were recruited. Blood samples were obtained for HIV serology and CD4 count, as well as cervical samples for HPV testing. HPV DNA detection and genotyping was performed using the SPF10/DEIA/LiPA25 technique which detects all mucosal HPV types by DEIA and identifies 25 HPV genotypes by LiPA version 1. Samples that tested positive but could not be genotyped were designated HPVX. Odds ratios (OR) and 95% confidence intervals (CI) were calculated by logistic regression, adjusting for possible confounding factors.en_US
dc.identifier.citationOdida et al.: HPV types, HIV and invasive cervical carcinoma risk in Kampala, Uganda: a case-control study. Infectious Agents and Cancer 2011 6:8. doi:10.1186/1750-9378-6-8en_US
dc.identifier.other10.1186/1750-9378-6-8
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1394
dc.language.isoenen_US
dc.publisherInfectious Agents and Canceren_US
dc.subjectHPV typesen_US
dc.subjectHIVen_US
dc.subjectCervical carcinomaen_US
dc.subjectKampalaen_US
dc.subjectUgandaen_US
dc.titleHPV types, HIV and invasive cervical carcinoma risk in Kampala, Uganda: a case-control studyen_US
dc.typeArticleen_US
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