Lopinavir/ritonavir significantly influences pharmacokinetic exposure of artemether/lumefantrine in HIV-infected Ugandan adults

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dc.contributor.authorByakika-Kibwika, Pauline
dc.contributor.authorLamorde, Mohammed
dc.contributor.authorOkaba-Kayom, Violet
dc.contributor.authorMayanja-Kizza, Harriet
dc.contributor.authorKatabira, Elly
dc.contributor.authorHanpithakpong, Warunee
dc.contributor.authorPakker, Nadine
dc.contributor.authorDorlo, Thomas P. C.
dc.contributor.authorTarning, Joel
dc.contributor.authorLindegardh, Niklas
dc.contributor.authorVries, Peter J. de
dc.contributor.authorBack, David
dc.contributor.authorKhoo, Saye
dc.contributor.authorMerry, Concepta
dc.date.accessioned2022-01-14T07:20:25Z
dc.date.available2022-01-14T07:20:25Z
dc.date.issued2012
dc.description.abstractTreatment of HIV/malaria-coinfected patients with antiretroviral therapy (ART) and artemisininbased combination therapy has potential for drug interactions. We investigated the pharmacokinetics of artemether, dihydroartemisinin and lumefantrine after administration of a single dose of 80/480 mg of artemether/ lumefantrine to HIV-infected adults, taken with and without lopinavir/ritonavir. Methods: A two-arm parallel study of 13 HIV-infected ART-naive adults and 16 HIV-infected adults stable on 400/100 mg of lopinavir/ritonavir plus two nucleoside reverse transcriptase inhibitors (ClinicalTrials.gov, NCT 00619944). Each participant received a single dose of 80/480 mg of artemether/lumefantrine under continuous cardiac function monitoring. Plasma concentrations of artemether, dihydroartemisinin and lumefantrine were measured.en_US
dc.identifier.citationByakika-Kibwika, P., Lamorde, M., Okaba-Kayom, V., Mayanja-Kizza, H., Katabira, E., Hanpithakpong, W., ... & Merry, C. (2012). Lopinavir/ritonavir significantly influences pharmacokinetic exposure of artemether/lumefantrine in HIV-infected Ugandan adults. Journal of antimicrobial chemotherapy, 67(5), 1217-1223. doi:10.1093/jac/dkr596en_US
dc.identifier.other10.1093/jac/dkr596
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1274
dc.language.isoenen_US
dc.publisherJournal of antimicrobial chemotherapyen_US
dc.subjectAntiretroviralsen_US
dc.subjectAntimalarialsen_US
dc.subjectDrug interactionsen_US
dc.titleLopinavir/ritonavir significantly influences pharmacokinetic exposure of artemether/lumefantrine in HIV-infected Ugandan adultsen_US
dc.typeArticleen_US
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