Latent Tuberculosis Infection Status of Pregnant Women in Uganda Determined Using QuantiFERON TB Gold-Plus

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dc.contributor.authorBongomin, Felix
dc.contributor.authorSsekamatte, Phillip
dc.contributor.authorNattabi, Gloria
dc.contributor.authorOlum, Ronald
dc.contributor.authorNinsiima, Sandra
dc.contributor.authorKyazze, Andrew Peter
dc.contributor.authorNabakka, Winnie
dc.contributor.authorKukunda, Rebecca
dc.contributor.authorCose, Stephen
dc.contributor.authorKibirige, Davis
dc.contributor.authorBatte, Charles
dc.contributor.authorKaddumukasa, Mark
dc.contributor.authorKirenga, Bruce J.
dc.contributor.authorNakimuli, Annettee
dc.contributor.authorBaruch Baluku, Joseph
dc.contributor.authorndia-Biraro, Irene A
dc.date.accessioned2023-01-22T18:28:38Z
dc.date.available2023-01-22T18:28:38Z
dc.date.issued2021
dc.description.abstractThe risk of progression of latent tuberculosis infection (LTBI) to active disease increases with pregnancy. This study determined the prevalence and risk factors associated with LTBI among pregnant women in Uganda. Methods. We enrolled 261 pregnant women, irrespective of gestational age. Participants who had known or suspected active tuberculosis (TB) on the basis of clinical evaluation or who had recently received treatment for TB were excluded. LTBI was defined as an interferon-γ concentration ≥0.35 IU/mL (calculated as either TB1 [eliciting CD4+ T-cell responses] or TB2 [eliciting CD8+ T-cell responses] antigen minus nil) using QuantiFERON TB Gold-Plus (QFT-plus) assay. Results. LTBI prevalence was 37.9% (n = 99) (95% confidence interval [CI], 32.3–44.0). However, 24 (9.2%) subjects had indeterminate QFT-plus results. Among participants with LTBI, TB1 and TB2 alone were positive in 11 (11.1%) and 18 (18.2%) participants, respectively. In multivariable analysis, human immunodeficiency virus (HIV) infection (adjusted odds ratio [aOR], 4.4 [95% confidence interval {CI}, 1.1–18.0]; P = .04) and age 30–39 years (aOR, 4.0 [95% CI, 1.2–12.7]; P = .02) were independently associated with LTBI. Meanwhile, smoking status, alcohol use, nature of residence, crowding index, and TB contact were not associated with LTBI. Conclusions. Our findings are in keeping with the evidence that HIV infection and advancing age are important risk factors for LTBI in pregnancy. In our setting, we recommend routine screening for LTBI and TB preventive therapy among eligible pregnant women.en_US
dc.identifier.citationBongomin, F., Ssekamatte, P., Nattabi, G., Olum, R., Ninsiima, S., Kyazze, A. P., ... & Andia-Biraro, I. (2021, June). Latent tuberculosis infection status of pregnant women in Uganda determined using QuantiFERON TB Gold-Plus. In Open forum infectious diseases (Vol. 8, No. 6, p. ofab241). US: Oxford University Press. DOI: 10.1093/ofid/ofab241en_US
dc.identifier.issn10.1093/ofid/ofab241
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/7119
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.subjectCD4+ T-cell and CD8+ T-cell TB responsesen_US
dc.subjectLatent tuberculosis infectionen_US
dc.subjectPregnancyen_US
dc.subjectRisk factorsen_US
dc.titleLatent Tuberculosis Infection Status of Pregnant Women in Uganda Determined Using QuantiFERON TB Gold-Plusen_US
dc.typeArticleen_US
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