Epidemiology of Microbial Keratitis in Uganda: A Cohort Study

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dc.contributor.authorArunga, Simon
dc.contributor.authorKintoki, Guyguy M.
dc.contributor.authorMwesigye, James
dc.contributor.authorAyebazibwe, Bosco
dc.contributor.authorOnyango, John
dc.contributor.authorBazira, Joel
dc.contributor.authorNewton, Rob
dc.contributor.authorGichuhi, Stephen
dc.contributor.authorLeck, Astrid
dc.contributor.authorMacleod, David
dc.contributor.authorHu, Victor H.
dc.contributor.authorBurton, Matthew J.
dc.date.accessioned2023-03-21T16:44:40Z
dc.date.available2023-03-21T16:44:40Z
dc.date.issued2020
dc.description.abstractTo describe the epidemiology of Microbial Keratitis (MK) in Uganda. Methods: We prospectively recruited patients presenting with MK at two main eye units in Southern Uganda between December 2016 and March 2018. We collected information on clinical history and presentation, microbiology and 3-month outcomes. Poor vision was defined as vision < 6/60). Results: 313 individuals were enrolled. Median age was 47 years (range 18–96) and 174 (56%) were male. Median presentation time was 17 days from onset (IQR 8–32). Trauma was reported by 29% and use of Traditional Eye Medicine by 60%. Majority presented with severe infections (median infiltrate size 5.2 mm); 47% were blind in the affected eye (vision < 3/60). Microbiology was available from 270 cases: 62% were fungal, 7% mixed (bacterial and fungal), 7% bacterial and 24% no organism detected. At 3 months, 30% of the participants were blind in the affected eye, while 9% had lost their eye from the infection. Delayed presentation (overall p = .007) and prior use of Traditional Eye Medicine (aOR 1.58 [95% CI 1.04–2.42], p = .033) were responsible for poor presentation. Predictors of poor vision at 3 months were: baseline vision (aOR 2.98 [95%CI 2.12–4.19], p < .0001), infiltrate size (aOR 1.19 [95%CI 1.03–1.36], p < .020) and perforation at presentation (aOR 9.93 [95% CI 3.70–26.6], p < .0001). Conclusion: The most important outcome predictor was the state of the eye at presentation, facilitated by prior use of Traditional Eye Medicine and delayed presentation. In order to improve outcomes, we need effective early interventions.en_US
dc.identifier.citationSimon Arunga, Guyguy M. Kintoki, James Mwesigye, Bosco Ayebazibwe, John Onyango, Joel Bazira, Rob Newton, Stephen Gichuhi, Astrid Leck, David Macleod, Victor H. Hu & Matthew J. Burton (2020) Epidemiology of Microbial Keratitis in Uganda: A Cohort Study, Ophthalmic Epidemiology, 27:2, 121-131, DOI: 10.1080/09286586.2019.1700533en_US
dc.identifier.urihttps://doi.org/10.1080/09286586.2019.1700533
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8259
dc.language.isoenen_US
dc.publisherOphthalmic Epidemiologyen_US
dc.subjectMicrobial keratitisen_US
dc.subjectBacterial keratitisen_US
dc.subjectFungal keratitisen_US
dc.subjectKeratitisen_US
dc.subjectBlindnessen_US
dc.titleEpidemiology of Microbial Keratitis in Uganda: A Cohort Studyen_US
dc.typeArticleen_US
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