The Relationship between HIV Type 1 Disease Progression and V3 Serotype in a Rural Ugandan Cohort

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dc.contributor.authorSenkaali, David
dc.contributor.authorMuwonge, Richard
dc.contributor.authorMorgan, Dilys
dc.contributor.authorYirrell, David
dc.contributor.authorWhitworth, James
dc.contributor.authorKaleebu, Pontiano
dc.date.accessioned2022-04-25T20:42:23Z
dc.date.available2022-04-25T20:42:23Z
dc.date.issued2004
dc.description.abstractAntigenic properties of the V3 region are reflected by HIV-1 serotypes. These may represent biological properties of the virus. We serotyped HIV-1 in 142 serum samples from participants in a rural Uganda cohort who seroconverted between August 1991 and December 2001. Clinical progression was assessed using Cox proportional hazards and Kaplan–Meier methods. Of 112 (79%) samples successfully serotyped, 36% were serotype A, 17% serotype B, 18% serotype C, and 29% serotype D. Median follow-up time, age at enrollment, and first CD4 count were similar in each serotype group. Clinical progression was faster for serotype D than other serotypes to AIDS or death, death, and CD4 count <200 cells/mm3 (all p < 0.05). HIV-1 V3 serotypes are associated with variations in the pathogenicity of HIV-1 and should be taken into account when studying the biological relevance of HIV-1 diversity.en_US
dc.identifier.citationSenkaali, D., Muwonge, R., Morgan, D., Virrell, D., Whitworth, J., & Kaleebu, P. (2004). The relationship between HIV type 1 disease progression and V3 serotype in a rural Ugandan cohort. AIDS Research & Human Retroviruses, 20(9), 932-937.https://doi.org/10.1089/aid.2004.20.932en_US
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/2919
dc.language.isoenen_US
dc.publisherAIDS Research & Human Retrovirusesen_US
dc.titleThe Relationship between HIV Type 1 Disease Progression and V3 Serotype in a Rural Ugandan Cohorten_US
dc.typeArticleen_US
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