Defining total-body AIDS-virus burden with Implications for Curative Strategies

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dc.contributor.authorEstes, Jacob D.
dc.contributor.authorKityo, Cissy
dc.contributor.authorSsali, Francis
dc.contributor.authorBeilman, Gregory J.
dc.contributor.authorSchacker, Timothy W.
dc.date.accessioned2023-02-06T17:44:14Z
dc.date.available2023-02-06T17:44:14Z
dc.date.issued2017
dc.description.abstractIn the quest for a functional cure or the eradication of HIV infection, it is necessary to know the sizes of the reservoirs from which infection rebounds after treatment interruption. Thus, we quantified SIV and HIV tissue burdens in tissues of infected nonhuman primates and lymphoid tissue (LT) biopsies from infected humans. Before antiretroviral therapy (ART), LTs contained >98% of the SIV RNA+ and DNA+ cells. With ART, the numbers of virus (v) RNA+ cells substantially decreased but remained detectable, and their persistence was associated with relatively lower drug concentrations in LT than in peripheral blood. Prolonged ART also decreased the levels of SIV- and HIV-DNA+ cells, but the estimated size of the residual tissue burden of 108 vDNA+ cells potentially containing replication-competent proviruses, along with evidence of continuing virus production in LT despite ART, indicated two important sources for rebound following treatment interruption. The large sizes of these tissue reservoirs underscore challenges in developing 'HIV cure' strategies targeting multiple sources of virus production.en_US
dc.identifier.citationEstes, J. D., Kityo, C., Ssali, F., Swainson, L., Makamdop, K. N., Del Prete, G. Q., ... & Schacker, T. W. (2017). Defining total-body AIDS-virus burden with implications for curative strategies. Nature medicine, 23(11), 1271-1276.https://doi.org/10.1038/nm.4411en_US
dc.identifier.issn1546-170X
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/7595
dc.language.isoenen_US
dc.publisherNature medicineen_US
dc.subjectAIDS-virusen_US
dc.subjectARTen_US
dc.subjectstrategiesen_US
dc.titleDefining total-body AIDS-virus burden with Implications for Curative Strategiesen_US
dc.typeArticleen_US
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