Antiplasmodial Quinones from the Rhizomes of Kniphofia foliosa

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dc.contributor.authorInduli, Martha
dc.contributor.authorGebru, Meron
dc.contributor.authorAbdissa, Negera Abdissa
dc.contributor.authorAkala, Hosea
dc.contributor.authorWekesa, Ingrid
dc.contributor.authorByamukama, Robert
dc.contributor.authorHeydenreich, Matthias
dc.contributor.authorMurunga, Sylvia
dc.contributor.authorDagne, Ermias
dc.contributor.authorYenesew, Abiy
dc.date.accessioned2021-12-13T12:42:17Z
dc.date.available2021-12-13T12:42:17Z
dc.date.issued2013
dc.description.abstractExtracts of the rhizomes of Kniphofia foliosa exhibited antiplasmodial activities against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with IC50 values of 3–5 g/mL. A phenyloxanthrone, named 10-acetonylknipholone cyclooxanthrone (1) and an anthraquinoneanthrone dimer, chryslandicin 10-methyl ether (2), were isolated from the rhizomes, along with known quinones, including the rare phenylanthraquinone dimers, joziknipholones A and B. The structures of these compounds were determined based on spectroscopic data. This is the second report on the occurrence of the dimeric phenylanthraquinones in nature. In an in vitro antiplasmodial assay of the isolated compounds, activity was observed for phenylanthraquinones, anthraquinone-anthrone dimers and dimeric phenylanthraquinones, with joziknipholone A being the most active. The new compound, 10-acetonylknipholonecyclooxanthrone, also showed anti-plasmodial activity. In an in vivo assay, knipholone anthrone displayed marginal antimalarial activityen_US
dc.identifier.citationInduli, M., Gebru, M., Abdissa, N., Akala, H., Wekesa, I., Byamukama, R., ... & Yenesew, A. (2013). Antiplasmodial quinones from the rhizomes of Kniphofia foliosa. Natural product communications, 8(9), 1934578X1300800920.https://doi.org/10.1177/1934578X1300800920en_US
dc.identifier.urihttps://doi.org/10.1177/1934578X1300800920
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/432
dc.language.isoenen_US
dc.publisherNatural product communicationsen_US
dc.titleAntiplasmodial Quinones from the Rhizomes of Kniphofia foliosaen_US
dc.typeArticleen_US
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