Seizure Activity And Neurological Sequelae In Ugandan Children Who Have Survived An Episode Of Cerebral Malaria

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dc.contributor.authorOpoka, Robert O.
dc.contributor.authorBangirana, Paul
dc.contributor.authorBoivin, Michael J.
dc.contributor.authorJohn, Chandy C.
dc.contributor.authorJustus Byarugaba, Justus
dc.date.accessioned2022-02-08T19:38:37Z
dc.date.available2022-02-08T19:38:37Z
dc.date.issued2009
dc.description.abstractSeizures are a common presenting feature in children with cerebral malaria (CM) and neurologic deficits have been described in survivors of CM. However few prospective studies have described the frequency of seizure activity and neurologic deficits in survivors of CM over time.Eighty-two children aged 3 to 12 years who survived an episode of CM were followed up and monitored for seizure activity and neurologic deficits at discharge, 3, 6 and 24 months. Seventy six children with uncomplicated malaria (UM) and 105 healthy community controls (CC) age 3 to 12 years were recruited as comparison groups and the frequency of seizures in the 6 to 24 month follow-up period was compared in the 3 groups.Cumulative incidence of seizures increased over time in children with CM, with a total of 2 of 76 children (2.6%) reporting seizures at 3 months, 3 of 74 children (4.1%) at 6 months and 11 of 68 children (16.2%) at 24 months (Chi square for trend = 9.36, P=0.002). In contrast, neurologic deficits almost completely resolved over time, occurring in 19 of 76 children with CM (25%) at discharge, 2 of 74 children (2.7%) at 6 months, and 1 of 68 (1.5%) children at 24 months.During the 24 months following a CM episode, neurologic deficits resolve but the cumulative incidence of seizures increases in children with CM. Neurologic impairment after an episode of CM may not be limited to the neurologic deficits seen at discharge.en_US
dc.identifier.citationOpoka, R. O., Bangirana, P., Boivin, M. J., John, C. C., & Byarugaba, J. (2009). Seizure activity and neurological sequelae in Ugandan children who have survived an episode of cerebral malaria. African health sciences, 9(2).en_US
dc.identifier.issn1680-6905
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/2009
dc.language.isoenen_US
dc.publisherAfrican health sciencesen_US
dc.subjectSeizures, cerebral malaria, neurological deficits, survivors, children.en_US
dc.titleSeizure Activity And Neurological Sequelae In Ugandan Children Who Have Survived An Episode Of Cerebral Malariaen_US
dc.typeArticleen_US
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