Risk Factors for Helminth, Malaria, and HIV Infection in Pregnancy in Entebbe, Uganda

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dc.contributor.authorWoodburn, Patrick William
dc.contributor.authorMuhangi, Lawrence
dc.contributor.authorHillier, Stephen
dc.contributor.authorNdibazza, Juliet
dc.contributor.authorBazanya Namujju, Proscovia
dc.contributor.authorKizza, Moses
dc.contributor.authorAmeke, Christine
dc.contributor.authorEmojong Omoding, Nicolas
dc.contributor.authorBooth, Mark
dc.contributor.authorMary Elliott, Alison
dc.date.accessioned2022-01-30T15:09:56Z
dc.date.available2022-01-30T15:09:56Z
dc.date.issued2009
dc.description.abstractInfections during pregnancy may have serious consequences for both mother and baby. Assessment of risk factors for infections informs planning of interventions and analysis of the impact of infections on health outcomes. To describe risk factors for helminths, malaria and HIV in pregnant Ugandan women before intervention in a trial of de-worming in pregnancy. The trial recruited 2,507 pregnant women between April 2003 and November 2005. Participants were interviewed and blood and stool samples obtained; location of residence at enrolment was mapped. Demographic, socioeconomic, behavioral and other risk factors were modelled using logistic regression. There was a high prevalence of helminth, malaria and HIV infection, as previously reported. All helminths and malaria parasitemia were more common in younger women, and education was protective against every infection. Place of birth and/or tribe affected all helminths in a pattern consistent with the geographical distribution of helminth infections in Uganda. Four different geohelminths (hookworm, Trichuris, Ascaris and Trichostrongylus) showed a downwards trend in prevalence during the enrolment period. There was a negative association between hookworm and HIV, and between hookworm and low CD4 count among HIV-positive women. Locally, high prevalence of schistosomiasis and HIV occurred in lakeshore communities. Interventions for helminths, malaria and HIV need to target young women both in and out of school. Antenatal interventions for malaria and HIV infection must continue to be promoted. Women originating from a high risk area for a helminth infection remain at high risk after migration to a lower-risk area, and vice versa, but overall, geohelminths seem to be becoming less common in this population. High risk populations, such as fishing communities, require directed effort against schistosomiasis and HIV infection.en_US
dc.identifier.citationWoodburn PW, Muhangi L, Hillier S, Ndibazza J, Namujju PB, et al. (2009) Risk Factors for Helminth, Malaria, and HIV Infection in Pregnancy in Entebbe, Uganda. PLoS Negl Trop Dis 3(6): e473. doi:10.1371/journal.pntd.0000473en_US
dc.identifier.other10.1371/journal.pntd.0000473
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1626
dc.language.isoenen_US
dc.publisherPLoS Negl Trop Disen_US
dc.subjectHelminthen_US
dc.subjectMalariaen_US
dc.subjectHIV Infectionen_US
dc.subjectPregnancyen_US
dc.subjectUgandaen_US
dc.titleRisk Factors for Helminth, Malaria, and HIV Infection in Pregnancy in Entebbe, Ugandaen_US
dc.typeArticleen_US
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