High Rate of HIV Resuppression After Viral Failure on First-line Antiretroviral Therapy in the Absence of Switch to Second-line Therapy

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High Rate of HIV Resuppression After Viral Failure on First-line Antiretroviral Therapy in the Absence of Switch to Second-line Therapy.pdf (133.06 KB)
Date
2014
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Publisher
Clinical infectious diseases
Abstract
In a randomized comparison of nevirapine or abacavir with zidovudine plus lamivudine, routine viral load monitoring was not performed, yet 27% of individuals with viral failure at week 48 experienced resuppression by week 96 without switching. This supports World Health Organization recommendations that suspected viral failure should trigger adherence counseling and repeat measurement before a treatment switch is considered.
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Keywords
HIV, failure, viral resuppression, resistance
Citation
Gupta, R. K., Goodall, R. L., Ranopa, M., Kityo, C., Munderi, P., Lyagoba, F., ... & Dunn, D. (2014). High rate of HIV resuppression after viral failure on first-line antiretroviral therapy in the absence of switch to second-line therapy. Clinical infectious diseases, 58(7), 1023-1026.https://doi.org/10.1093/cid/cit933
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https://nru.uncst.go.ug/handle/123456789/7974
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Medical and Health Sciences