Parasite infection is associated with Kaposi’s sarcoma associated herpesvirus (KSHV) in Ugandan women

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dc.contributor.authorWakeham, Katie
dc.contributor.authorWebb, Emily L.
dc.contributor.authorSebina, Ismail
dc.contributor.authorMuhangi, Lawrence
dc.contributor.authorMiley, Wendell
dc.contributor.authorJohnson, W. Thomas
dc.contributor.authorNdibazza, Juliet
dc.contributor.authorElliott, Alison M.
dc.contributor.authorWhitby, Denise
dc.contributor.authorNewton, Robert
dc.date.accessioned2022-01-30T14:37:00Z
dc.date.available2022-01-30T14:37:00Z
dc.date.issued2011
dc.description.abstractImmune modulation by parasites may influence susceptibility to bacteria and viruses. We examined the association between current parasite infections, HIV and syphilis (measured in blood or stool samples using standard methods) and antibodies against Kaposi’s sarcoma herpesvirus (KSHV), measured by ELISA, in 1915 stored plasma samples from pregnant women in Entebbe, Uganda. Seroprevalence of KSHV was higher in women with malaria parasitaemia (73% vs 60% p = 0.01), hookworm (67% vs 56% p = 0.001) and Mansonella perstans (69% vs 59% p = 0.05); seroprevalence increased with increasing intensity of hookworm infection (p < 0.001[trend]). No associations were found for HIV, five other parasites or active syphilis. These effects were not explained by socioeconomic status or education. Specific parasite infections are associated with presence of antibodies against KSHV, perhaps mediated via their effect on immune function.en_US
dc.identifier.citationWakeham et al.: Parasite infection is associated with Kaposi’s sarcoma associated herpesvirus (KSHV) in Ugandan women. Infectious Agents and Cancer 2011 6:15. doi:10.1186/1750-9378-6-15en_US
dc.identifier.other10.1186/1750-9378-6-15
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1623
dc.language.isoenen_US
dc.publisherInfectious Agents and Canceren_US
dc.subjectParasite infectionen_US
dc.subjectKaposi’s sarcoma associated herpesvirus (KSHV)en_US
dc.subjectUgandan womenen_US
dc.titleParasite infection is associated with Kaposi’s sarcoma associated herpesvirus (KSHV) in Ugandan womenen_US
dc.typeArticleen_US
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