Association between oral candidiasis and low CD4+ count among HIV positive patients in Hoima Regional Referral Hospital

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dc.contributor.authorNanteza, Martina
dc.contributor.authorTusiime, Jayne B.
dc.contributor.authorKalyango, Joan
dc.contributor.authorKasangaki, Arabat
dc.date.accessioned2022-02-02T14:54:12Z
dc.date.available2022-02-02T14:54:12Z
dc.date.issued2014
dc.description.abstractThe aim of this study was to determine the prevalence of Human Immune Virus (HIV) related oral lesions and their association with Cluster of Differentiation 4 (CD4+) count among treatment naïve HIV positive patients. Methods: This was a descriptive and analytical cross sectional study. Participants were 346 treatment naïve HIV positive adult patients. These were consecutively recruited from Hoima Regional Referral hospital between March and April 2012. Data collection involved interviews, oral examinations and laboratory analysis. Results: A total of 168(48.6%) participants had oral lesions. The four commonest lesions were oral candidiasis (24.9%, CI = 20.6-29.7%), melanotic hyperpigmentation (17.3%, CI = 13.7-21.7%), kaposi sarcoma (9.3%, CI = 6.6-12.8%) and Oral Hairy Leukoplakia (OHL) (5.5%, CI = 3.5-8.4%). There was significant association between oral candidiasis and immunosuppression measured as CD4+ less than 350 cells/mm3 (OR = 2.69, CI = 1.608-4.502, p < 0.001). Oral candidiasis was the only oral lesion significantly predictive of immunosuppression (OR = 2.56, CI = 1.52-4.30, p < 0.001) with a Positive Predictive Value (PPV) of 48.2%, Negative Predictive Value (NPV) of 74.3%, 38.1% sensitivity and specificity of 81.4%. Conclusion: Oral candidiasis can be considered as a marker for immunesuppression, making routine oral examinations essential in the management of HIV positive patients.en_US
dc.identifier.citationNanteza et al.: Association between oral candidiasis and low CD4+ count among HIV positive patients in Hoima Regional Referral Hospital. BMC Oral Health 2014 14:143. doi:10.1186/1472-6831-14-143en_US
dc.identifier.other10.1186/1472-6831-14-143
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1765
dc.language.isoenen_US
dc.publisherBMC Oral Healthen_US
dc.subjectOral candidiasisen_US
dc.subjectLow CD4+ counten_US
dc.subjectHIV positive patientsen_US
dc.titleAssociation between oral candidiasis and low CD4+ count among HIV positive patients in Hoima Regional Referral Hospitalen_US
dc.typeArticleen_US
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