Immunological Signaling During Herpes Simplex Virus-2 and Cytomegalovirus Vaginal Shedding After Initiation of Antiretroviral Treatment

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dc.contributor.authorNason, Martha C.
dc.contributor.authorPatel, Eshan U.
dc.contributor.authorKirkpatrick, Allison R.
dc.contributor.authorProdger, Jessica L.
dc.contributor.authorShahabi, Kamnoosh
dc.contributor.authorTobian, Aaron A. R.
dc.contributor.authorGianella, Sara
dc.contributor.authorKalibbala, Sarah
dc.contributor.authorSsebbowa, Paschal
dc.contributor.authorKaul, Rupert
dc.contributor.authorGray, Ronald H.
dc.contributor.authorQuinn, Thomas C.
dc.contributor.authorSerwadda, David
dc.contributor.authorReynolds, Steven J.
dc.contributor.authorRedd, Andrew D.
dc.date.accessioned2022-01-20T21:38:21Z
dc.date.available2022-01-20T21:38:21Z
dc.date.issued2016
dc.description.abstractVaginal proinflammatory cytokine expression during herpes virus reactivation was examined in human immunodeficiency virus infected women before and after initiation of antiretroviral therapy (ART). Vaginal swabs were screened for levels of cytokines interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, tumor necrosis factor (TNF)-α, and interferon- γ. The relative risk (RR) of herpes simplex virus-2 or cytomegalovirus (CMV) shedding being associated with cytokine levels above the median were estimated. Herpes simplex virus-2 shedding was significantly associated with higher levels of IL-6 (RR = 1.4, P = .003) and TNF-α (RR = 1.3, P = .010), whereas CMV shedding was associated with higher IL-6 (RR = 1.3, P = .006) and IL-2 (RR = 1.4, P = .01). The association of viral shedding with higher IL-6 levels suggests that herpes virus reactivation may be playing a role in immune activation after ART initiation.en_US
dc.identifier.citationNason, M. C., Patel, E. U., Kirkpatrick, A. R., Prodger, J. L., Shahabi, K., Tobian, A. A., ... & Redd, A. D. (2016, April). Immunological signaling during herpes simplex virus-2 and cytomegalovirus vaginal shedding after initiation of antiretroviral treatment. In Open forum infectious diseases (Vol. 3, No. 2). Oxford University Press. DOI: 10.1093/ofid/ofw073en_US
dc.identifier.other10.1093/ofid/ofw073
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1366
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.subjectHIVen_US
dc.subjectHSV-2en_US
dc.subjectCMVen_US
dc.subjectCytokineen_US
dc.subjectViral sheddingen_US
dc.titleImmunological Signaling During Herpes Simplex Virus-2 and Cytomegalovirus Vaginal Shedding After Initiation of Antiretroviral Treatmenten_US
dc.typeArticleen_US
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