Combination Therapy with Fluconazole and Flucytosine for Cryptococcal Meningitis in Ugandan Patients with AIDS

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dc.contributor.authorKizza, Harriet Mayanja
dc.contributor.authorOishi, Kazunori
dc.contributor.authorMitarai, Satoshi
dc.contributor.authorYamashita, Hiroshi
dc.contributor.authorNalongo, Kisembo
dc.contributor.authorWatanabe, Kiwao
dc.contributor.authorIzumi, Takashi
dc.contributor.authorJungala, Ococi
dc.contributor.authorAugustine, Kaddhu
dc.contributor.authorMugerwa, Roy
dc.contributor.authorNagatake, Tsuyoshi
dc.contributor.authorMatsumoto, Keizo
dc.date.accessioned2022-05-20T04:56:55Z
dc.date.available2022-05-20T04:56:55Z
dc.date.issued1998
dc.description.abstractWe performed a randomized trial in which combination therapy with fluconazole and shortterm flucytosine was compared with fluconazole monotherapy in 58 patients with AIDS-associated cryptococcal meningitis (CM). Thirty of these patients were randomized to receive combination therapy with fluconazole, 200 mg once a day for 2 months, and flucytosine, 150 mg/(kg·d) for the first 2 weeks, and 28 were randomized to receive monotherapy with fluconazole at the same dose for 2 months. Patients in both groups who survived for 2 months received fluconazole as maintenance therapy at a dose of 200 mg three times per week for 4 months. The combination therapy prevented death within 2 weeks and significantly increased the survival rate among these patients (32%) at 6 months over that among patients receiving monotherapy (12%) (P = .022). The combination therapy also resulted in a significant decrease in the severity of headache after 1 month of treatment, compared with monotherapy (P = .005). No serious adverse reactions were observed in patients receiving either regimen. These data indicate that treatment with fluconazole and short-term flucytosine is a cost-effective and safe regimen that improves the quality of life for patients with AIDSassociated CM in developing countries where human immunodeficiency virus is endemic.en_US
dc.identifier.citationKizza, H. M., Oishi, K., Mitarai, S., Yamashita, H., Nalongo, K., Watanabe, K., ... & Matsumoto, K. (1998). Combination therapy with fluconazole and flucytosine for cryptococcal meningitis in Ugandan patients with AIDS. Clinical Infectious Diseases, 26(6), 1362-1366.https://doi.org/10.1086/516372en_US
dc.identifier.issn1537-6591
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/3270
dc.language.isoenen_US
dc.publisherClinical Infectious Diseasesen_US
dc.subjecthiv, acquired immunodeficiency syndrome, cryptococcal meningitis, cost effectiveness, flucytosine, headache, combined modality therapy, developing countries, fluconazole,survival rate, quality of lifeen_US
dc.titleCombination Therapy with Fluconazole and Flucytosine for Cryptococcal Meningitis in Ugandan Patients with AIDSen_US
dc.typeArticleen_US
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