Acute Toxicity, Antipyretic and Antinociceptive Study of the Crude Saponin from an Edible Vegetable: Vernonia Amygdalina Leaf

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dc.contributor.authorAdiukwu, Paul Chukwuemeka
dc.contributor.authorAgaba, Amon
dc.contributor.authorNambatya, Grace
dc.contributor.authorAdzu, Bulus
dc.contributor.authorImanirampa, Lawrence
dc.contributor.authorTwinomujuni, Silvano
dc.contributor.authorTwikirize, Osbert
dc.contributor.authorAmanya, Martin
dc.contributor.authorEzeonwumelu, Joseph Obiezuchukwujekwu
dc.contributor.authorOloro, Joseph
dc.contributor.authorOkoruwa, Godwin Aiyabalu
dc.contributor.authorKatusiime, Barbra
dc.date.accessioned2022-03-08T10:16:53Z
dc.date.available2022-03-08T10:16:53Z
dc.date.issued2012
dc.description.abstractVernonia amygdalina is commonly used for food and health purposes. Processing of the leaf for food is aimed at removing bitter tasting antinutritional principles like saponins. This study was designed to determine the antipyretic and antinociceptive property of the crude saponin from Vernonia amygdalina leaf. Standard procedure for antipyretic study using Saccharomyces cerevisiae induced pyrexia in rats; and acetic acid induced writhe, hot plate and cold tail flick tests for antinociceptive study in mice were used. Data for the crude saponin showed significant (P ≤ 0.05) dose dependent anal temperature decrease. The antinociceptive data in mice was significant (P ≤ 0.05) in the writhing test contrary to the cold tail flick test. In acute toxicity study, an LD50 of 5.1523 g/kg using oral route indicated it was practically non-toxic. Finding suggests that Vernonia amygdalina leaf prepared as diet could be of potential benefit to ailing persons with fever and/or pains, if processing technique adopts minimal loss of principles like saponins.en_US
dc.identifier.citationAdiukwu, P. C., Amon, A., Nambatya, G., Adzu, B., Imanirampa, L., Twinomujuni, S., ... & Katusiime, B. (2012). Acute toxicity, antipyretic and antinociceptive study of the crude saponin from an edible vegetable: Vernonia amygdalina leaf. International Journal of Biological and Chemical Sciences, 6(3), 1019-1028.https://doi.org/10.4314/ijbcs.v6i3.9en_US
dc.identifier.issn1997-342X
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/2549
dc.language.isoenen_US
dc.publisherInternational Journal of Biological and Chemical Sciencesen_US
dc.subjectMice, oral, pain, pyrexia, raten_US
dc.titleAcute Toxicity, Antipyretic and Antinociceptive Study of the Crude Saponin from an Edible Vegetable: Vernonia Amygdalina Leafen_US
dc.typeArticleen_US
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