Osteosarcoma gene prioritization through combined bioinformatics analysis

Simple item page
dc.contributor.authorCabrera-Andrade, Alejandro
dc.contributor.authorLópez-Cortés, Andrés
dc.contributor.authorBarigye, Stephen J.
dc.contributor.authorPérez-Castillo, Yunierkis
dc.date.accessioned2023-02-10T09:39:22Z
dc.date.available2023-02-10T09:39:22Z
dc.date.issued2017
dc.description.abstractOsteosarcoma (OS) is a rare genetic disease that represents 20% of all types of malignant and benign neoplasms of the bone, and 2% of pediatric cancers. Therefore, our aim in this study is to generate a consensus gene list associated with the pathogenicity of OS by using several theoretical approaches that let to propose new drivers associated to this sarcoma, and also possible biomarkers. Firstly, we evaluated the consensus between 9 prioritization strategies to early determine pathogenic genes related to OS. From these genes, we performed a communality analysis in the protein-protein interaction network further enrichment analysis. The consensus prioritized gene list consisted of 1295 genes. Our results revealed that consensus strategy proposes genes related to control in the cell cycle that describe the etiology of cancer in general, and prioritizes not only suppressors already described for OS such as RB1 and TP53, but also postulates new candidates that would help to describe its pathogenesis.en_US
dc.identifier.citationCabrera-Andrade, A., López-Cortés, A., Paz-y-Miño, C., Barigye, S. J., Pérez-Castillo, Y., Munteanu, C. R., & Tejera, E. Osteosarcoma gene prioritization through combined bioinformatics analysis.doi: 10.3390/mol2net-03-04605en_US
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/7744
dc.language.isoenen_US
dc.publisherMol2Neten_US
dc.subjectConsensus analysisen_US
dc.subjectGene periodizationen_US
dc.subjectOsteosarcomaen_US
dc.subjectCommunality analysisen_US
dc.titleOsteosarcoma gene prioritization through combined bioinformatics analysisen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Osteosarcoma gene prioritization through combined bioinformatics analysis.pdf
Size:
57.73 KB
Format:
Adobe Portable Document Format
Description:
Osteosarcoma gene prioritization through combined bioinformatics analysis
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Medical and Health Sciences