Pharmacokinetics and pharmacodynamics of intravenous artesunate during severe malaria treatment in Ugandan adults

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dc.contributor.authorByakika-Kibwika, Pauline
dc.contributor.authorLamorde, Mohammed
dc.contributor.authorMayito, Jonathan
dc.contributor.authorNabukeera, Lillian
dc.contributor.authorMayanja-Kizza, Harriet
dc.contributor.authorKatabira, Elly
dc.contributor.authorHanpithakpong, Warunee
dc.contributor.authorObua, Celestino
dc.contributor.authorPakker, Nadine
dc.contributor.authorLindegardh, Niklas
dc.contributor.authorTarning, Joel
dc.contributor.authorde Vries, Peter J.
dc.contributor.authorMerry, Concepta
dc.date.accessioned2022-01-12T12:32:38Z
dc.date.available2022-01-12T12:32:38Z
dc.date.issued2012
dc.description.abstractSevere malaria is a medical emergency with high mortality. Prompt achievement of therapeutic concentrations of highly effective anti-malarial drugs reduces the risk of death. The aim of this study was to assess the pharmacokinetics and pharmacodynamics of intravenous artesunate in Ugandan adults with severe malaria. Methods: Fourteen adults with severe falciparum malaria requiring parenteral therapy were treated with 2.4 mg/kg intravenous artesunate. Blood samples were collected after the initial dose and plasma concentrations of artesunate and dihydroartemisinin measured by solid-phase extraction and liquid chromatography-tandem mass spectrometry. The study was approved by the Makerere University Faculty of Medicine Research and Ethics Committee (Ref2010-015) and Uganda National Council of Science and Technology (HS605) and registered with ClinicalTrials.gov (NCT01122134).en_US
dc.identifier.citationByakika-Kibwika et al.: Pharmacokinetics and pharmacodynamics of intravenous artesunate during severe malaria treatment in Ugandan adults. Malaria Journal 2012 11:132. doi:10.1186/1475-2875-11-132en_US
dc.identifier.other10.1186/1475-2875-11-132
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1230
dc.language.isoenen_US
dc.publisherMalaria Journalen_US
dc.subjectPharmacokineticsen_US
dc.subjectPharmacodynamicsen_US
dc.subjectIntravenousen_US
dc.subjectArtesunateen_US
dc.subjectSevere malariaen_US
dc.titlePharmacokinetics and pharmacodynamics of intravenous artesunate during severe malaria treatment in Ugandan adultsen_US
dc.typeArticleen_US
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