New azetidine-3-carbonyl-N-methyl-hydrazino derivatives of fluoroquinolones: synthesis and evaluation of antibacterial and anticancer properties

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dc.contributor.authorGovinda Rajulu, G.
dc.contributor.authorBhojya Naik, Halehatty S.
dc.contributor.authorCharan Kumar, G.
dc.contributor.authorRamaraj, S.
dc.contributor.authorSambasivam, Ganesh
dc.contributor.authorPoonimangadu Koppolu, Kesavan
dc.date.accessioned2023-07-12T16:20:31Z
dc.date.available2023-07-12T16:20:31Z
dc.date.issued2014
dc.description.abstractA series of nine new N-(substituted azetidine-3 -carbonyl)-N-methyl-hydrazino derivatives at C-7 position of fluoroquinolones were designed and synthesized through multistep synthesis. The synthesized compounds were characterized by 1H NMR, 13C NMR, ESI–MS and IR. The new compounds were tested for their in vitro antimicrobial and anti-proliferative activity. Out of the nine derivatives, compound 6i exhibited good antibacterial activity by inhibiting the growth of Methicillin-sensitive Staphylococcus aureus, Methicillin-resistant S. aureus and ATCC 35218 Escherichia coli (MIC: 0.25–16.00 lg/mL). Compounds 6c, 6g–h are displayed good growth inhibition against MCF-7 Breast carcinoma, HCT-116 Colon carcinoma and A549 Lung adenocarcinoma cell lines. Compound 6h is the most active against MCF-7 cell line with superior growth inhibition compared to ciprofloxacin and reference anticancer drug SAHA.en_US
dc.identifier.citationRajulu, G. G., Naik, H. S. B., Kumar, G. C., Ramaraj, S., Sambasivam, G., & Koppolu, K. P. (2014). New azetidine-3-carbonyl-N-methyl-hydrazino derivatives of fluoroquinolones: synthesis and evaluation of antibacterial and anticancer properties. Medicinal Chemistry Research, 23, 2856-2868. 10.1007/s00044-013-0873-0en_US
dc.identifier.uri10.1007/s00044-013-0873-0
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/9064
dc.language.isoenen_US
dc.publisherMedicinal Chemistry Researchen_US
dc.subjectSynthesisen_US
dc.subjectReductive aminationen_US
dc.subjectFluoroquinolonesen_US
dc.subjectAntibacterial activityen_US
dc.subjectAnticancer activityen_US
dc.titleNew azetidine-3-carbonyl-N-methyl-hydrazino derivatives of fluoroquinolones: synthesis and evaluation of antibacterial and anticancer propertiesen_US
dc.typeArticleen_US
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